Participation of the Cerebellum in Problem Solving

小脑参与解决问题

• 批准号: 6556074
• 负责人: JAMES C HOUK
• 金额: $ 32.35万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6556074
• 关键词: Macaca; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; cerebellum; cerebral cortex; clinical research; cognition; dentate nucleus; functional magnetic resonance imaging; histochemistry /cytochemistry; human subject; method development; problem solving

DESCRIPTION (provided by applicant): The network of investigators proposed here will explore how problem solving activities engage different loops and circuits that patch together channels through a cognitive map in the dentate nucleus of the cerebellum. Our proposed activities represent a unique focus on developing tasks and methods for cross-species comparisons, bridge building between anatomical and functional data, and joint consideration of both motor and cognitive functions of the cerebellum. Dr. Strick will generate plans for the construction of an unfolded map of the dentate projections to the cerebral cortex in non-human primates. Dr. Miller will generate plans to study how single unit activity is distributed across this map when monkeys engage in cognitive tasks. The PI, Dr. Houk, will explore conceptual and computational models of signal processing in the modular networks in which the dentate channels participate. Our consultant, Dr. Lewis, will work with Dr. Strick to develop correspondences between molecular staining of human and monkey dentate. Dr. Kim will develop high-resolution imaging methods for exploring human dentate. Drs. Fiez and Reber will formulate plans for using this constellation of tools to document the activation patterns that occur in the cerebellar dentate nucleus when humans are executing problem-solving tasks. Interactions with our consultant Dr. Mesulam will help us explore correlations with neurological disorders and the attentional network spread across the cerebral cortex. Similarly, interactions with Dr. Lewis will help us explore correlations with schizophrenia and other psychological disorders.

描述（由申请人提供）：此处提出的研究人员网络将探讨解决问题活动的不同循环和电路如何通过小脑齿状核中的认知图将通道结合在一起。我们提出的活动代表着开发跨物种比较的任务和方法的独特关注，解剖学和功能数据之间的桥梁建设以及对小脑运动和认知功能的共同考虑。 Strick博士将制定计划，以建造非人类灵长类动物的大脑皮层的牙齿预测图。当猴子从事认知任务时，米勒博士将制定计划，以研究如何在该地图上分布单位活动。 Houk博士将探索齿状通道参与的模块化网络中信号处理的概念和计算模型。我们的顾问Lewis博士将与Strick博士合作，开发人类和猴子齿状分子染色之间的对应关系。 Kim博士将开发用于探索人齿状的高分辨率成像方法。博士。 Fiez和Reber将制定计划使用该工具星座来记录小脑牙齿核核中发生的激活模式，当时人类正在执行解决问题的任务。与我们的顾问Mesulam博士的互动将帮助我们探索与神经系统疾病的相关性，以及分布在大脑皮层中的注意力网络。同样，与刘易斯博士的互动将帮助我们探索与精神分裂症和其他心理疾病的相关性。