Exercise Training and Vagal-Cardiac Function in Elderly

老年人运动训练与迷走神经心脏功能

• 批准号: 6470886
• 负责人: Xiangrong Shi
• 金额: $ 31.58万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6470886
• 关键词: aerobic exercise; baroreflex; blood pressure; blood volume; clinical research; heart function; human old age (65+); human subject; human therapy evaluation; neurophysiology; physical fitness; postural hypotension; vagus nerve

DESCRIPTION (provided by applicant): It has been demonstrated in young adults that aerobic exercise training enhances cardiac parasympathetic (or vagal) nerve activity. This improved vagal-cardiac function is cardioprotective. Recently, we found that a compromised arterial blood pressure (ABP) regulation in elderly adults was associated with an age-related vagal dysfunction. Since aging is accompanied by chronic physical inactivity, questions remain as to whether aerobic exercise training can reverse the vagal dysfunction manifest in the elderly. We hypothesize that elderly adults with greater relative aerobic capacity will have greater autonomic neural control of the heart than their age matched counterparts and that the enhanced vagal-cardiac modulation resulting from exercise training will assist in APB stability at rest and during orthostatic challenge. We will test these hypotheses by evaluating vagally mediated control of cardiac function and baroreflex control of blood pressure in trained and in untrained elderly subjects aged 65 - 75 years. Selective muscarinic and beta1-adrenergic blockade will be used to determine the effects of endurance training on the specific neural area of the autonomic neural control of the heart affected by exercise training. Additionally, the effect of exercise training will be assessed by comparing untrained elderly subjects before and after one year of moderate intensity aerobic exercise training. Our long-term objectives are to understand the albeit regulatory mechanisms of blood pressure and blood volume due to age and to provide the basis for the use of prophylactic measure to improve the quality of human life.

描述（由申请人提供）：已在年轻人中得到证实 有氧运动训练可以增强心脏副交感神经（或迷走神经） 神经活动。这种改善的迷走神经心脏功能具有心脏保护作用。 最近，我们发现动脉血压（ABP）调节受损 老年人的迷走神经功能障碍与年龄相关。自从 衰老伴随着长期缺乏身体活动，但问题仍然存在 有氧运动训练是否可以逆转迷走神经功能障碍 老年人。我们假设有氧运动相对较多的老年人 能力将比他们的年龄对心脏有更大的自主神经控制 匹配的对应物，并且增强的迷走神经心脏调节产生 运动训练将有助于休息时和运动期间的 APB 稳定性 立位挑战。我们将通过评估迷走神经来检验这些假设 心脏功能的介导控制和血压的压力反射控制 在经过培训和未经培训的 65 - 75 岁老年受试者中进行。选择性 毒蕈碱和β1-肾上腺素能阻断剂将用于确定效果 自主神经特定神经区域的耐力训练 心脏的控制受到运动训练的影响。另外，效果 将通过比较未经训练的老年受试者来评估运动训练 一年中等强度有氧运动训练前后。我们的 长期目标是了解监管机制 血压和血容量因年龄而提供使用依据 提高人类生活质量的预防措施。