CORE--CELL BIOLOGY AND IMMUNOTOXICOLOGY

核心--细胞生物学和免疫毒理学

基本信息

批准号：
6575643
负责人：
MARK E LEID
金额：
$ 7.89万
依托单位：
OREGON STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至 2003-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6575643
关键词：
apoptosis biological signal transduction biomedical facility cell biology cell differentiation cell growth regulation cytokine environmental health environmental toxicology immunotoxicity

项目摘要

Description: The Cell Biology and Immunotoxicology Research Core serves as a biologically oriented complement to the Chemical/Analytical Cores of the OSUEHS Center to provide a focus of relevance to human health for application of the chemical and physical approaches and expertise available within the other Cores. Thus the Core provides a medium for the initiation of research projects in directions that otherwise may not have been pursued. Core leadership has changed from Dr. Barnes (who left OSU in 1997) to Dr. Leid. Drs. Bayne, Kerkvliet and Reed continue to be in this Core and are joined by recent Center investigators: Drs. Greenwood, Hagen, Ishmael and Vella. Dr. Hedstrom (Associate member of Center) also remains associated with this research core. In addition, there are 2 postdoctoral, 17 graduate students and 12 research assistants. The objectives of this Core are to provide an intellectual resource for pursuits into cellular signaling and hormonal/cytokine control of growth, differentiation, early development and mechanisms of cell death. Specific projects by investigators of this Core include: analysis of T cells with regard to TCDD or Ah receptor and peroxisome proliferators; immunomodulation by xenobiotics; oxidative stress, including mitochondrial dysfunction, glutathione and protein thiols, with regard to cell death and immunotoxicity; age-related effects on mitochondrial functions. This Core serves as a biologically oriented complement to the Chemical/Analytical Cores to provide "a focus of relevance to human health for application of chemical and physical approaches". This Core has assisted with 97 publications since 1995 with about 16 being collaborative studies. Eight past collaborative projects are listed [Dr. Kerkvliet (4); Dr. Barnes (2); Dr. Reed (1);and Dr. Leid (1)]. Future plans include additional joint projects with the more recent Center investigators, e.g., projects between Drs. Ishmael and Leid (cloning PAR. alpha transcriptional coactivators); Drs. Kerkvliet and Ishmael (new cell cultures models to assess cell cycle after exposure to nongenotoxic carcinogens); Drs. Reed and Hagen role of glutathione, iron and vitamin E on myocytes; Drs. Kerkvliet, Reed and Hagen (role of glutathione and vitamin E in apoptosis of lymphocytes); Drs. Kerkvliet, Vella, Leid and Hedstrom (TCDD effects on dendritic cells). Drs. Kerkvliet and Vella will provide the immunological expertise for this Core with Drs. Leid and Reed providing biochemical and molecular expertise. This Core provides biological bridging with the other Cores and Center investigators with support for experimental design fostered through workshops and monthly laboratory meetings.

描述：细胞生物学和免疫毒理学研究核心是以生物学为导向的补充对化学/分析核心的补充 Osuehs中心为应用提供与人类健康相关的重点可以提供的化学和物理方法和专业知识其他核心。因此，核心为启动研究提供了一种媒介否则可能没有追求的指示项目。核领导力从巴恩斯博士（1997年离开OSU）变成了莱伊德博士。博士。 Bayne，Kerkvliet和Reed继续存在于此核心中，并加入了最近的中心调查员：博士。格林伍德，哈根，以实玛利和维拉。 Hedstrom博士（中心副成员）也与此相关联研究核心。此外，还有2个博士后，17名研究生和12名研究助理。该核心的目标是提供追求蜂窝信号的智力资源和激素/细胞因子控制生长，分化，早期发展和细胞死亡的机制。调查人员的特定项目该核心包括：TCDD或AH受体的T细胞分析以及过氧化物酶体增殖物；异种生物的免疫调节；氧化应激，包括线粒体功能障碍，谷胱甘肽和蛋白硫醇，带有关于细胞死亡和免疫毒性；与年龄有关线粒体的影响功能。该核心是针对生物学的补充化学/分析核心提供“与人类健康相关的重点化学和物理方法的应用”。该核心有助于自1995年以来，有97个出版物，约有16个是协作研究。八列出了过去的协作项目[Dr. Kerkvliet（4）;巴恩斯博士（2）；里德（Reed）博士（1）； Leid博士（1）]。未来计划包括额外的联合与更新的中心调查人员的项目，例如博士。 Ishmael和Leid（克隆par。Alpha转录共激活因子）；博士。 Kerkvliet和Ishmael（评估细胞周期的新细胞培养模型暴露于非核癌致癌物后）；博士。里德和哈根角色肌细胞上的谷胱甘肽，铁和维生素E；博士。 Kerkvliet，Reed和Hagen （谷胱甘肽和维生素E在淋巴细胞凋亡中的作用）；博士。 Kerkvliet，Vella，Leid和Hedstrom（TCDD对树突状细胞的影响）。博士。 Kerkvliet和Vella将为此提供免疫学专业知识 DRS的核心。 Leid和Reed提供了生化和分子专业知识。该核心提供了其他核心和中心的生物桥接通过研讨会培养的实验设计的支持的研究人员和每月实验室会议。