CORE--NEURAL AND DEVELOPMENTAL TOXICOLOGY

核心——神经和发育毒理学

• 批准号: 6585556
• 负责人: Kenneth Reynolds Reuhl
• 金额: $ 17.41万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585556
• 关键词: biomedical facility; developmental neurobiology; environmental toxicology; neurotoxins; toxicant interaction; toxin metabolism

The mission of the Neural and Developmental Toxicology Core is to serve as a focus for mechanistic research in neurotoxicology and developmental toxicology. The prime directive of this core is to elucidate mechanisms of selective vulnerability as related to toxicant effects on specific brain cells and regions. This core is directed by Dr. Ken R. Reuhl, Ph.D. with Dr. Herbert E. Lowndes, Ph.D. serving as co-director. This core is comprised of approximately 10 full-time faculty with diverse research expertise in behavioral, cellular and molecular indices of nerve cell injury and degeneration. Vulnerability has been a consistent theme for this core and acts as a focal point for 3 research affinity groups: Developmental Neurotoxicology, Neural Metabolism and Models of Neuronal Disease. Subdivision of the Core into affinity groups significantly improved organization and promoted hypothesis-directed research. Each affinity group addresses specific aims related to that groups research focus; e.g., the Developmental Neurotoxicity group explores the involvement of toxicant-induced disruption of cytoskeletal proteins, adhesion molecules and axonal guidance cues in mediating brain cell dysgenesis. During the present funding period (1993-1997), there have been several changes in personnel; although two members left the program, four faculty have been added with expertise in developmental, behavioral and chemical toxicology. Core members have been highly productive publishing more than 80 papers many of which resulted from inter-and intra-Core collaborations. Plans for program growth and future directions include continued research collaboration among Center and non-Center members, with selective vulnerability as the focal issue. Molecular techniques will be emphasized to facilitate mechanistic explorations. The Core leadership recognizes the importance of whole animal corroboration of molecular findings and, therefore, proposes inclusion of systems and behavioral analyses in future studies.

神经和发育毒理学核心的使命是 作为神经毒理学和机械研究的重点 发育毒理学。该核心的主要指令是阐明 选择性脆弱性的机制与毒物对毒性的影响有关 特定的脑细胞和区域。该核心由Ken R. Reuhl博士执导 博士与Herbert E. Lowndes博士博士一起担任联合导演。这个核心是 由大约10个全职教职员工组成 神经细胞损伤的行为，细胞和分子指数方面的专业知识 和变性。脆弱性一直是该核心和 作为3个研究亲和力组的焦点：发展 神经毒理学，神经代谢和神经元疾病的模型。 将核心分为亲和力组的细分显着改善 组织并促进了假设指导的研究。每个亲和力组 解决与该小组研究重点相关的特定目的；例如， 发育神经毒性组探讨了毒物诱导的参与 细胞骨架蛋白，粘附分子和轴突引导的破坏 介导脑细胞失调的线索。在目前的资金期 （1993-1997），人员发生了一些变化。虽然两个 成员离开了该计划，已增加了四个教师的专业知识 发育，行为和化学毒理学。核心成员已经 高产性发行80多篇论文，其中许多是由 核心内部合作。计划增长和未来的计划 方向包括中心之间的持续研究合作 非中心成员，选择性脆弱性是焦点问题。 分子技术将被强调以促进机械 探索。核心领导认识到整个动物的重要性 分子发现的佐证，因此提出包含 未来研究中的系统和行为分析。