CORE--MARINE MODELS OF HUMAN DISEASES

核心——人类疾病海洋模型

• 批准号: 6587618
• 负责人: Patrick Joseph Walsh
• 金额: $ 7.35万
• 依托单位: UNIVERSITY OF MIAMI CORAL GABLES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-22 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587618
• 关键词: Aplysia; aquatic biology; aquatic organism; biological models; biomedical facility; biotechnology; cellular immunity; disease /disorder model; environmental health; fish; fresh water environment; genetically modified animals; genetics; histopathology; humoral immunity; model design /development; neurofibroma; neurotoxicology; pathologic process; saltwater environment; sharks; toxin metabolism; zebrafish

Description (provided by applicant): In the second Research Core of this Center, the unifying theme is the use of marine and freshwater model systems for environmental health-related research. In general, the use of model systems as surrogates for the study of pathological states related to the environment stems from several advantages over the direct use of mammalian system. These systems include: 1) Damselfish Neurofibromatosis, 2) Toadfish, 3) Shark Immunology, 4) Aplysia, 5) Transgenic Fishes. The research in the marine models of human diseases is highly interdisciplinary, in that, investigators in this Research Core share knowledge and approaches in several areas on virtually a daily basis. First, there is a great deal of interactivity in basic animal care, maintenance and husbandry techniques. Second, from an experimental standpoint, expertise is available on a number of different levels of biological organization, including biochemistry and molecular biology, pathogen biology, in vitro cell culture and manipulations (including electrophysiology and embryology), and whole-animal physiological and serological methodology. When combined with the interests and expertise available in the Marine and Freshwater Toxins and Human Health Research Core, the investigators believe they are a powerful resource for each of the individual scientists in the MFBS, and for the investigators and mission of NIEHS.

描述（申请人提供）：在第二个研究核心中 中心，统一的主题是使用海洋和淡水模型系统 用于与环境健康有关的研究。通常，使用模型 系统作为研究与该病理状态有关的替代 环境源于直接使用哺乳动物的好处 系统。这些系统包括：1）雌性神经纤维瘤病，2）蟾蜍， 3）鲨鱼免疫学，4）Aplysia，5）转基因鱼类。 人类疾病的海洋模型的研究很高 跨学科，因为这项研究核心分享的研究人员 几乎每天都有几个领域的知识和方法。第一的， 基本动物护理，维护和 饲养技术。第二，从实验的角度来看，专业知识是 在许多不同级别的生物组织上可用， 包括生物化学和分子生物学，病原体生物学，体外细胞 培养和操纵（包括电生理学和胚胎学），以及 全动物生理和血清学方法论。合并时 海洋和淡水毒素的利益和专业知识以及 人类健康研究核心，调查人员认为他们是一个强大的 MFB中的每个科学家的资源，以及 Niehs的调查人员和任务。