CHILDBIRTH-RELATED PELVIC FLOOR INJURY

分娩相关的盆底损伤

• 批准号: 6536092
• 负责人: KENNETH J. LEVENO
• 金额: $ 18.54万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536092
• 关键词: biomedical equipment; birth; catecholamines; clinical research; cytoskeletal proteins; fecal incontinence; female; gene expression; human subject; immunocytochemistry; injury; interview; labor complications; laboratory rat; longitudinal human study; muscle contraction; neurons; neuropeptide Y; pelvis; postpartum; questionnaires; smooth muscle; urinary incontinence; urinary tract; women's health

DESCRIPTION (Adapated from Applicant's Description): This proposal is submitted in response to RFA HD-99-003 "Basic Science Research on Female Pelvic Floor Disorders." Described in this application is a comprehensive multidisciplinary basic and clinical science research program focused specifically on the relationship of childbirth to pelvic floor injury. Three research components are presented to include (1) a prospective analysis of the relationship between precise obstetrical events and subsequent pelvic floor dysfunction in 11,000 primiparous women; (2) a randomized trial of the effects of coached maternal pushing during the second stage of labor on postpartum pelvic floor function; and (3) utilization of a novel animal model to study the effects of vaginal trauma during pregnancy on lower urinary tract smooth muscle contractility and contractile protein gene expression. Sample sizes for the aims described in this application are based upon ad hoc power analyses. This proposal also describes the qualifications and experience of basic and clinical investigators at the University of Texas Southwestern Medical Center and Parkland Hospital who are committed to the study of childbirth related pelvic floor injury. Included are individuals with expertise in maternal-fetal medicine, urogynecology, and smooth muscle physiology. Existing resources include operational laboratories to support the basic science research described, a well functioning computerized perinatal database to support analysis of precise obstetrical events related to pelvic floor injury and an established, well-functioning infrastructure capable of completing randomized clinical trials. Integral to this infrastructure is a well-functioning state-of-the-art urogynecologic clinical laboratory. The major focus of this application is on its theme of multidisciplinary basic and clinical research focused specifically on childbirth which is the singular most important, predisposing factor to pelvic floor injury.

描述（根据申请人的描述进行适应）：此提案是 根据RFA HD-99-003提交的“女性基础科学研究 骨盆地板障碍。 多学科基础和临床科学研究计划的重点 特别是关于分娩与骨盆底损伤的关系。 提出了三个研究组件，包括（1）前瞻性分析 精确的产科事件与随后的骨盆之间的关系 11,000名初学妇女的地板功能障碍； （2）一项随机试验 在劳动的第二阶段教练的母亲推动的影响 产后骨盆底功能； （3）利用新型动物模型 研究怀孕期间阴道创伤对尿道较低的影响 平滑肌收缩力和收缩蛋白基因表达。样本 本应用程序中描述的目标的尺寸是基于临时功率 分析。该建议还描述了 德克萨斯大学西南大学的基础和临床研究人员 医疗中心和帕克兰医院，他们致力于研究 分娩相关的骨盆底损伤。包括个人 孕产妇医学，泌尿原生和平滑肌方面的专业知识 生理。现有资源包括运营实验室以支持 所描述的基础科学研究，功能良好的计算机围产期 数据库支持与骨盆有关的精确产科事件的分析 地板伤害和既定功能良好的基础设施 完成随机临床试验。该基础设施不可或缺的是 功能良好的最先进的泌尿原始临床实验室。这 该应用的主要重点是其多学科基本的主题 临床研究专门针对分娩，这是单数 最重要的，诱发骨盆底损伤的因素。