BIOENERGETICS OF EXERCISE-INDUCED MENSTRUAL DISTURBANCES

运动引起的月经紊乱的生物能量学

• 批准号: 6536176
• 负责人: NANCY Imboden WILLIAMS
• 金额: $ 44.22万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-10 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536176
• 关键词: aerobic exercise; amenorrhea; bioenergetics; blood chemistry; body composition; caloric dietary content; calorimetry; clinical research; epidemiology; female; hormone metabolism; human subject; interview; longitudinal human study; menstrual cycle; menstrual cycle disorder; nutrient intake activity; reproductive hormone; urinalysis; weight loss

DESCRIPTION: (Scanned from the applicant's abstract) The suppression of menstrual cyclicity due to strenuous exercise can cause infertility, severe bone demineralization, increase fracture risk, and possibly increase the risk of cardiovascular disease. Recent findings in humans and animals have strongly suggested that exercise-induced menstrual disturbances are primarily caused by low energy availability and not by other factors, such as the physical stress of exercise per se. While some studies have quantified energy balance associated with short-term decreases in plasma levels of reproductive hormones, the bioenergetics associated with the induction and reversal of clinically recognized menstrual disturbances in exercising women remain unclear. The first specific aim of this proposal is to test the hypothesis that there is a direct relationship between the severity of exercise-induced menstrual disturbances and the magnitude of negative energy balance. In addition to weight loss, crosssectional studies in humans suggest that exercise-induced menstrual disturbances are associated with adaptive mechanisms to conserve energy, i.e., alterations in circulating metabolic hormones and substrates, and reductions in components of 24 h energy expenditure such as metabolic rate. Since in vivo and in vitro studies using animal models have suggested mechanistic roles for key metabolic hormones and substrates in the modulation of GnRH neuronal activity with changes in energy balance, prospective studies in humans are now necessary to identify the time course and magnitudes of change of potential key metabolic signals during the development of EIMD. The second specific aim of this proposal is to test the hypothesis that exercise-induced menstrual disturbances are triggered by the development of a particular metabolic state defined by adaptive mechanisms to conserve energy. The significance of this research relates to conditions of infertility, delayed puberty, anovulation, anorexia nervosa, exercise-induced amenorrhea, and the recently identified high incidence of luteal phase disturbances and anovulatory cycles in women exercising even at recreational levels. We expect the results of these studies to provide new and useful information for making specific recommendations regarding the exercise and dietary practices concomitant with maintaining normal, ovulatory menstrual cycles and adequate levels of circulating estrogen and progesterone. The results will also expand our understanding of the mechanism of the modulation of reproductive function by energy availability.

描述：（从申请人的摘要中扫描） 由于剧烈运动引起的月经循环性会导致不育，严重 骨脱矿化，增加断裂风险，并可能增加风险 心血管疾病。人类和动物的最新发现强烈 建议运动引起的月经障碍主要是由 低能量可用性，而不是其他因素，例如身体压力 锻炼本身。虽然一些研究已经量化了能量平衡 与血浆生殖激素水平的短期降低相关， 与临床上的诱导和逆转相关的生物能学 在行使妇女中公认的月经障碍尚不清楚。 该提议的第一个具体目的是检验 运动引起的月经的严重程度之间的直接关系 干扰和负能量平衡的幅度。此外 体重减轻，人类的横断面研究表明锻炼引起的 月经障碍与自适应机制有关 能量，即循环代谢激素和底物的改变，以及 降低24小时的能量消耗的组件，例如代谢率。 由于体内和使用动物模型的体外研究表明 调制中关键代谢激素和底物的机械作用 GNRH神经元活动随着能量平衡的变化，前瞻性研究 现在，必须在人类中确定时间课程和幅度 EIMD开发过程中潜在的主要代谢信号的变化。这 该提议的第二个具体目的是检验以下假设。 锻炼引起的月经障碍是通过发展的 由自适应机制定义的特定代谢状态以节省能量。 这项研究的意义与不育条件延迟有关 青春期，发肠，神经性厌食症，运动引起的闭经和 最近确定了黄体期障碍和无排卵的高发生率 即使在娱乐水平上运动的女性循环。我们期望结果 在这些研究中，提供了新的和有用的信息来制作特定的 有关锻炼和饮食习惯的建议 保持正常，排卵的月经和足够的水平 循环雌激素和孕酮。结果也将扩大我们的 理解通过 能源可用性。