Adult Asthma: Biology, Society and Environment

成人哮喘：生物学、社会和环境

• 批准号: 6518211
• 负责人: Paul D Blanc
• 金额: $ 71.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518211
• 关键词: asthma; clinical research; criminal behavior; disease /disorder etiology; employment /unemployment; environmental contamination; health economics; human subject; longitudinal human study; low socioeconomic status; pathologic process; respiratory disorder epidemiology; rhinitis; social psychology; socioeconomics

DESCRIPTION (provided by applicant): Environmental, biological, and psychosocial factors can all separately influence the disease burden in asthma. As yet, no studies have taken into account all three categories of factors together, to examine their relative contributions to the disease burden and investigate whether their cumulative effects can explain the health disparities of at-risk populations, either additively or synergistically. Asthma is an ideal chronic condition in which to delineate the potential linkages among biological mechanisms, social factors, and physical environments and, more specifically, to show how these linkages may lead to health disparities. Study Hypotheses: 1) There are socioeconomic status (SES) differentials in the disease burden of asthma; 2) Environmental, biological, and psychosocial factors are linked to the asthma disease burden additively, if not synergistically; and 3) The variance in SES differentials of disease burden will be substantially explained by modeling that takes specific environmental, biological, and psychosocial factors into account. Methods: This proposed study will make use of an established panel of 590 adults with asthma of varying severity. We propose to supplement these survey data with 500 home site visits in which we will directly gather environmental, biological, and psychosocial data. Specific environmental risk factors we will quantify include: allergen sensitization, home allergens, ETS exposure, and indoor air quality. We will also assess perceived stress and social support. In addition, we will link subjects to other potential exposures through external data sets. We will also administer a follow-up survey to investigate the combined influence of environmental, biological, and psychosocial exposures in explaining SES disparities in the disease burden of asthma. This study combines a multidisciplinary team of researchers with expertise in clinical medicine, social sciences, epidemiology, psychology, endocrinology, asthma treatment and prevention, and biostatistics. Anticipated Results and Significance: The proposed investigation will have sufficient power to detect differences in the proportions of outcomes between two groups in the range of 10-15 percent at the 0.05 level for dichotomous outcomes. This project addresses a major research need and can be a basis for the development of public policies to address environmentally related and other health disparities in adult asthma.

描述（由申请人提供）：环境、生物和 心理社会因素均可单独影响哮喘的疾病负担。 迄今为止，还没有研究考虑到所有三类因素 一起检查它们对疾病负担的相对贡献， 研究它们的累积效应是否可以解释健康差异 增加或协同地减少高危人群。哮喘是一种 理想的慢性病，​​可以描述之间的潜在联系 生物机制、社会因素和物理环境等等 具体来说，是为了表明这些联系如何导致健康差异。学习 假设： 1) 不同群体之间存在社会经济地位 (SES) 差异 哮喘的疾病负担； 2) 环境、生物和社会心理 如果没有的话，因素与哮喘疾病负担也有相关性 协同作用； 3) 疾病负担的 SES 差异的方差 将通过采用特定环境的建模来进行实质性解释， 考虑到生物和社会心理因素。方法：本研究建议 将利用由 590 名患有不同程度哮喘的成年人组成的既定小组 严重程度。我们建议通过 500 次家庭实地考察来补充这些调查数据 我们将直接收集环境、生物和社会心理信息 数据。我们将量化的具体环境风险因素包括： 过敏原 致敏、家庭过敏原、ETS 暴露和室内空气质量。我们将 还评估感知压力和社会支持。另外，我们将链接 通过外部数据集受到其他潜在风险的影响。我们也会 进行后续调查以调查综合影响 解释 SES 时的环境、生物和社会心理暴露 哮喘疾病负担的差异。这项研究结合了 具有临床医学专业知识的多学科研究人员团队， 社会科学、流行病学、心理学、内分泌学、哮喘治疗和 预防和生物统计学。预期结果和意义： 拟议的调查将有足够的力量来发现差异 两组之间的结果比例在 10-15% 范围内 二分结果的水平为 0.05。该项目涉及一项重大研究 需要并可以作为制定公共政策的基础来解决 成人哮喘的环境相关和其他健康差异。