A Novel Animal Model of Cocaine Addiction

可卡因成瘾的新型动物模型

• 批准号: 6515858
• 负责人: David Charles Stephen Roberts
• 金额: $ 21.62万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515858
• 关键词: chordate locomotion; circadian rhythms; cocaine; disease /disorder model; drug addiction; eating; laboratory rat; model design /development; motivation; psychopharmacology; reinforcer; self medication

DESCRIPTION: Cocaine addiction in North America is a medical problem with profound social and financial cost. Approximately 2 million Americans use cocaine habitually, and those seeking treatment find it extraordinarily difficult to abstain and relapse rates are high. A medication that would help control the cravings for cocaine during the early stages of therapy would help retain patients in treatment programs. An animal model is essential for testing potentially therapeutic drugs and for evaluating the underlying neurobiology of drug abuse. This proposal will address two key features of the addictive process. The first is a progressive increase in the motivation to take cocaine and the second is the emergence of binge patterns of drug use. Cocaine self-administration in rats will be used to model these fundamental aspects of human drug taking. A novel procedure has been developed that permits continual access to cocaine (during discrete trials) throughout the 24 dark/light cycle. Different patterns of intake (either circadian or binge-like) are engendered depending on the dose and frequency of the trials. The overall objective of this proposal is to define the critical factors that model the addictive process. Specifically we will (1) define the parameters that affect the transition from controlled (circadian) intake to binge-like, dysregulated patterns of self-administration, (2) identify factors that lead to motivational changes across the cocaine addiction process (such as total intake, pattern to intake, and drug-free periods) and (3) characterize individual differences in the development of binge-like patterns of intake and an increased motivation to self-administer cocaine.

描述：可卡因成瘾在北美是一个医学问题 巨大的社会和财务成本。大约 200 万美国人使用 习惯性吸食可卡因，寻求治疗的人发现它非同寻常 戒除困难且复发率高。一种有帮助的药物 在治疗的早期阶段控制对可卡因的渴望会有所帮助 让患者参与治疗计划。动物模型对于测试至关重要 潜在的治疗药物和评估潜在的神经生物学 药物滥用。该提案将解决成瘾性的两个关键特征 过程。首先是吸食可卡因的动机逐渐增加 二是出现了酗酒模式。可卡因 大鼠的自我给药将用于模拟这些基本方面 人类吸毒。已经开发出一种新颖的程序，可以连续 在 24 个黑暗/光明周期中获取可卡因（在离散试验期间）。 产生不同的摄入模式（昼夜节律或暴饮暴食） 取决于试验的剂量和频率。总体目标 该提案旨在定义模拟成瘾的关键因素 过程。具体来说，我们将（1）定义影响的参数 从控制（昼夜节律）摄入到暴饮暴食、失调的转变 自我管理的模式，（2）识别导致动机的因素 可卡因成瘾过程中的变化（例如总摄入量、模式） 摄入量和禁药期）和（3）表征了个体差异 形成暴饮暴食的摄入模式以及增加的动机 自行服用可卡因。