Molecular Epidemiology of Myelodysplastic Syndromes

骨髓增生异常综合征的分子流行病学

• 批准号: 6515090
• 负责人: Sara S. Strom
• 金额: $ 7.5万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515090
• 关键词: alcoholism /alcohol abuse; clinical research; cytochrome P450; diet; dyes; dyserythropoietic anemia; gene environment interaction; genetic markers; genetic susceptibility; glutathione transferase; human subject; neoplasm /cancer epidemiology; petroleum oil; radiobiology; smoking; tobacco abuse

Although many reports have been published on the etiology of different types of leukemia, little is known about the risk factors associated with the myelodysplastic syndromes (MDS). Even less is known about the role that genetic susceptibility plays in the development of these syndromes. We propose to conduct a pilot case-control study of 180 MDS patients registered at the U. of Texas M. D. Anderson Cancer Center (MDACC) and 180 controls selected from friends and spouses who accompany patients to different MDACC clinics. Controls will be matched to the cases on age, sex, ethnicity, and state of residence. We propose to accrue 130 new cases and 130 controls to add to the 100 participants (50 cases and 50 controls) already collected. Epidemiological and demographic information obtained by personal interviews will be integrated with clinical, including cytogenetics, and genotypic markers. All participants will be genotyped for the following markers associated with activation and detoxification of chemical carcinogens (CYP2E1, CYP1A1, CYP1B1, GSTT1, GSTM1, GSTP1, NQO1, and MPO). This pilot study will provide insight in the understanding about the role that these genetic markers, along with epidemiological and clinical risk factors play in the identification of people at risk of MDS development. This study will provide data for a large multicenter study. The identification of risk factors associated with the development of MDS is an important health concern, as it could lead to the eventual prevention of this syndrome and consequent reduction in the incidence of AML.

尽管已经发表了有关不同类型白血病的病因的许多报道，但对与骨髓增生性综合征（MDS）相关的危险因素知之甚少。关于遗传易感性在这些综合征发展中起着的作用，知之甚少。我们建议对德克萨斯州M. D. Anderson癌症中心（MDACC）注册的180名MDS患者进行试验病例对照研究，并从陪同患者到不同MDACC诊所的朋友和配偶中选出的180个对照组。控件将与年龄，性别，种族和居住状态的案件相匹配。我们建议累积130例新病例和130个对照，以添加已收集的100名参与者（50例和50个对照）。通过个人访谈获得的流行病学和人口统计学信息将与临床，包括细胞遗传学和基因型标记。所有参与者将进行基因分型，以用于与化学致癌物的激活和解毒相关的以下标记（CYP2E1，CYP1A1，CYP1B1，GSTT1，GSTT1，GSTM1，GSTM1，GSTP1，NQO1和MPO）。这项试点研究将提供有关对这些遗传标志物的作用以及流行病学和临床危险因素在识别有MDS发育风险的人中起作用的见解。这项研究将为大型多中心研究提供数据。与MDS发展相关的危险因素的识别是一个重要的健康问题，因为它可能导致最终预防该综合征，并导致AML发病率降低。