Exercise Intervention for Depressed Smokers

对抑郁吸烟者的运动干预

• 批准号: 6553092
• 负责人: KRISTIN S VICKERS
• 金额: $ 6.96万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6553092
• 关键词: adolescence (12-20); behavior modification; behavioral /social science research tag; clinical research; clinical trials; comorbidity; counseling; depression; drug abuse therapy; education evaluation /planning; exercise; female; human middle age (35-64); human subject; human therapy evaluation; interview; nicotine replacement; outcomes research; patient monitoring device; personal log /diary; questionnaires; sign /symptom; smoking cessation; therapy compliance; tobacco abuse education; young adult human (21-34)

DESCRIPTION (provided by applicant): This application will serve as the foundation on which the Principal Investigator will build a line of research dedicated to the area of nicotine dependence treatment for depressed smokers. Cigarette smoking is the single most important preventable cause of morbidity, mortality, and excess health costs in the United States. Depressive symptoms have been identified as a major barrier to smoking abstinence, and depressed women attempting smoking cessation may be particularly vulnerable to relapse related to negative affect. Consequently, researchers have identified the need for smoking interventions specifically targeting depressed women. Mood management interventions have been shown to increase the smoking abstinence rates for depressed smokers. Exercise is effective in the treatment of depression and is an aid for smoking cessation among women, but has not been studied in depressed smokers. Further, exercise interventions for smoking cessation have not included pharmacotherapy (e.g., nicotine patch). The proposed project addresses the current lack of effective smoking interventions specifically targeting depressed women. The specific aims of this pilot study are: 1) to evaluate the feasibility of an individually-tailored exercise intervention for depressed smokers, 2) to evaluate in a pilot randomized trial the effect of the exercise intervention compared to a health education intervention on the smoking abstinence rates at the end of treatment (week ten) and at week 24, 3) to examine the effect of the exercise intervention on depressive symptoms, and 4) to examine the relationship between baseline depressive symptoms, exercise adherence, and change in exercise levels among those assigned to the exercise intervention. We hypothesize that the exercise intervention will be feasible and associated with higher seven-day point-prevalence smoking abstinence rates than the health education intervention at weeks 10 and 24. Sixty women between the ages of 18 and 50 who are classified as depressed, based on a Center for Epidemiologic Studies - Depression Scale (CES-D) score of greater than or equal too $16, will be randomly assigned to a ten week individual program of: 1) individually-tailored, moderate-intensity exercise or 2) health education. Participants in both conditions will receive nicotine patch therapy and nicotine dependence counseling. Data collected will provide feasibility and effect size estimates to be used for an R01 submission. The ultimate goal of this work is to develop effective interventions that will reduce future tobacco-related morbidity and mortality among depressed smokers.

描述（由申请人提供）： 该应用将作为主要研究人员将建立专门针对吸烟者尼古丁依赖治疗领域的研究线的基础。吸烟是美国发病率，死亡率和过度健康成本的最重要的唯一可预防原因。抑郁症状已被确定为戒烟的主要障碍，试图戒烟的抑郁妇女可能特别容易受到与负面影响有关的复发。因此，研究人员已经确定了针对抑郁症妇女的吸烟干预措施的必要性。情绪管理干预措施已被证明可以增加吸烟者的戒烟率。运动可有效治疗抑郁症，是妇女戒烟的帮助，但尚未在吸烟者中进行研究。此外，戒烟的运动干预措施不包括药物治疗（例如尼古丁贴剂）。拟议的项目解决了目前缺乏有效的吸烟干预措施，专门针对抑郁症的妇女。这项试验研究的具体目的是：1）评估吸烟者对抑郁症的单独运动干预措施的可行性，2）在试点随机试验中评估运动干预措施与健康干预措施对吸烟对戒烟率在治疗结束时的戒烟率相比（第10周）和在接受抑制症状的效果，以及4.4的症状效果，以及4.4的抑制作用，以及4.3周的抑制作用，以及4次抑郁症状的效果，以及4分配给运动干预措施的人的依从性和运动水平的变化。 We hypothesize that the exercise intervention will be feasible and associated with higher seven-day point-prevalence smoking abstinence rates than the health education intervention at weeks 10 and 24. Sixty women between the ages of 18 and 50 who are classified as depressed, based on a Center for Epidemiologic Studies - Depression Scale (CES-D) score of greater than or equal too $16, will be randomly assigned to a ten week individual program of: 1) individually-tailored,中等强度运动或2）健康教育。两种情况下的参与者都将接受尼古丁补丁治疗和尼古丁依赖咨询。收集的数据将提供可行性和效果大小估计，用于R01提交。这项工作的最终目标是制定有效的干预措施，以减少吸烟者中与烟草相关的发病率和死亡率。