Phytotherapy of Prostateic Symptoms (POPW)

前列腺症状的植物疗法 (POPW)

• 批准号: 6587399
• 负责人: E DAVID CRAWFORD
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6587399
• 关键词: aging; alternative medicine; benign prostate hyperplasia; chemotherapy; clinical research; cooperative study; disease /disorder prevention /control; ethnic group; human subject; human therapy evaluation; male; medicinal plants; method development; patient oriented research; plant extracts; urinary tract disorder

DESCRIPTION (provided by applicant): Lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) are common in the aging male There are few well-designed, long term, multi-center, randomized clinical trials comparing the subjective and objective outcomes of physiotherapy of prostatic symptoms (POPS) AIM 1 To collaborate with a research consortium to design and conduct a multi-center randomized phase III clinical trial comparing saw palmetto, Pygeum africanum, or a placebo for treatment of symptomatic BPH AIM 2 To recruit and randomize 300 men (in two years) with symptomatic BPH who meet the protocol guidelines AIM 3 To design and implement a prospective randomized controlled trial for treatment of BPH that will determine which of the following predict successful treatment outcomes patient characteristics, AUA symptoms score, uroflow rate, and prostate size AIM 4 To design and implement recruitment interventions among racial and ethnic minority men and procedures for the maintenance of the long-term participation of study subjects.

描述（由申请人提供）： 提示良性前列腺梗阻 (BPO) 的下尿路症状 (LUTS) 在老年男性中很常见。很少有精心设计的长期、多中心、随机临床试验比较前列腺症状物理治疗的主观和客观结果。持久性有机污染物） 目标 1 与研究联盟合作设计并进行一项多中心随机 III 期临床试验，比较锯棕榈、非洲臀果木或安慰剂治疗症状性 BPH 目标 2 招募并随机分组 300 名符合方案指南的有症状 BPH 男性（两年内） 目标 3 设计和实施一项治疗 BPH 的前瞻性随机对照试验，确定以下哪一项可预测成功的治疗结果：患者特征、AUA 症状评分、尿流率和前列腺大小 目标 4 设计和实施针对少数族裔男性的招募干预措施以及维持研究对象长期参与的程序。