Effects of Estrogen and Cannabinoids on Learning

雌激素和大麻素对学习的影响

基本信息

批准号：
6515884
负责人：
JILL M DANIEL
金额：
$ 1.35万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/6515884
关键词：
autoradiography behavioral /social science research tag behavioral habituation /sensitization brain cannabinoid receptor cannabinoids central nervous system estrogens hippocampus hormone regulation /control mechanism hormone therapy laboratory rat learning memory ovariectomy performance receptor binding

项目摘要

DESCRIPTION (provided by applicant) There is growing evidence to indicate that there is an interaction between the biologically active constituent of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), and the ovarian hormone, estrogen, in the central nervous system. However, little information is currently available regarding the functional consequences of this interaction on behavior. Additionally, despite the fact that the behavioral effects of other drugs of abuse are influenced by estrogenic status, the behavioral effects of delta 9-THC in female animal models have not been investigated. The experiments in the proposed study will test the following hypotheses: 1) Estrogen replacement will attenuate the disruptive effects of systemically administered delta 9-THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. 2) Estrogen replacement will differentially affect levels of cannabinoid receptor binding, as measured by quantitative receptor autoradiography, in brain areas implicated in learning and memory and will potentiate decreases in cannabinoid receptor binding induced by chronic administration of delta 9-THC. 3) Estrogen replacement will accelerate the development of delta 9-THC-induced behavioral tolerance in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. 4) Estrogen replacement will attenuate the disruptive effects of intrahippocampally-administered delta 9-THC on overall response rate and percent errors in ovariectomized rats responding under a multiple schedule of repeated acquisition and performance of behavioral chains. These results will provide, for the first time, information regarding the interactive effects of estrogen and delta 9-THC on behavior.

描述（由申请人提供）越来越多的证据表明大麻的生物活性成分，三角洲9-四氢大麻酚（Delta 9-thc）和中枢神经中的卵巢激素，雌激素系统。但是，目前几乎没有有关这种相互作用对行为的功能后果。此外，尽管如此其他虐待药物的行为影响受到的事实受到雌激素状态，三角洲9-THC对雌性动物的行为影响尚未研究模型。拟议的研究中的实验将测试以下假设：1）雌激素替代将减弱系统管理的DELTA 9-THC对整体响应的破坏性影响卵巢切除大鼠的率和误差百分比重复获取和行为链的性能的时间表。 2）雌激素替代将差异地影响大麻素受体的水平通过定量受体放射自显影测量的结合，在大脑区域与学习和记忆有关，将增强大麻素的减少慢性给药Delta 9-THC诱导的受体结合。 3）雌激素更换将加速增量9-THC诱导的行为的发展卵巢切除型大鼠的公差，在多个时间表下响应行为链的重复采集和性能。 4）雌激素替换将减轻公寓内管理的三角洲9-THC总体响应率和卵巢切除型大鼠的错误百分比在多个时间表行为链的重复采集和性能。这些结果将会第一次提供有关交互作用的信息雌激素和三角洲的行为。