Development of an Exercise Intervention for Alcoholics

酗酒者运动干预的开发

• 批准号: 6420886
• 负责人: RICHARD A BROWN
• 金额: $ 20.1万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420886
• 关键词: adult human (21+); aerobic exercise; alcoholic beverage consumption; alcoholism /alcohol abuse education; alcoholism /alcohol abuse therapy; alternative medicine; behavioral /social science research tag; behavioral medicine; cardiovascular function; clinical trials; depression; drug detection; educational resource design /development; emotions; handbook; human subject; human therapy evaluation; interview; patient oriented research; questionnaires; relapse /recurrence; respiratory function; technology /technique development

Intervention to increase in alcohol dependent patients represents a potentially useful yet relatively unexplored strategy for preventing relapse. There are currently no established exercise interventions for use with this population. The long-term objectives of this research program are to improve treatment options for alcoholics by developing and establishing the efficacy of a supervised aerobic exercise intervention (SAE) and to advance knowledge of the relationship between physical activity and alcohol use outcomes. In the present application, we propose to develop a supervised aerobic exercise (SAE) intervention for alcohol dependent patients and to conduct a preliminary, randomized clinical trial, examining its efficacy in comparison to a brief advice (BA) exercise intervention. In the first phase of this project (YEAR 1), we will develop and pilot the SAE intervention with 20 patients completing an intensive day and evening alcohol and drug treatment program. We will also develop a behavioral component to promote exercise adherence, including clinician and patient manuals. In the second phase (Years 2 & 3) we will conduct a preliminary randomized trial with 50 sedentary alcohol dependent patients to examine the efficacy of the SAE intervention relative to the BA comparison condition over a six-month follow-up period. Based on effect sizes derived from this preliminary trial, the exercise intervention will be further refined and readied for larger-scale clinical trials. We expect that, relative to the BA condition, participants, randomized to the SAE condition will demonstrate better alcohol use outcomes as well as improved moor, depressive symptoms, and cardiorespiratory fitness. If the efficacy of this intervention can be established in this trial and in subsequent clinical trials, alcohol dependent patients will be provided with a valuable adjunct or alternative to traditional alcohol treatment.

依赖酒精的患者增加的干预是一种潜在有用但相对尚未开发的防止复发的策略。目前尚无与该人群一起使用的既定运动干预措施。该研究计划的长期目标是通过开发和建立监督有氧运动干预（SAE）的疗效，并提高对体育活动与酒精使用结果之间关系的了解来改善酒精中毒的治疗选择。在本应用中，我们建议对依赖酒精的患者进行监督的有氧运动（SAE）干预措施，并进行初步的，随机的临床试验，并检查其与简短建议（BA）运动干预相比的功效。在该项目的第一阶段（第1年），我们将开发和试行SAE干预措施，20名患者完成了一项密集的白天和晚上酒精和药物治疗计划。我们还将开发一种行为成分来促进运动依从性，包括临床医生和患者手册。在第二阶段（2和3年），我们将与50名久坐酒精依赖的患者进行初步随机试验，以检查SAE干预相对于BA比较条件在六个月的随访期内的疗效。根据该初步试验得出的效果大小，将进一步完善运动干预措施，并准备大规模临床试验。我们预计，相对于BA条件，参与者随机分配到SAE条件将表现出更好的酒精使用结果，以及改善的摩尔，抑郁症状和心肺适应性。如果可以在此试验中确定这种干预措施的功效，并且在随后的临床试验中，将为依赖酒精的患者提供有价值的辅助或替代传统酒精治疗。