DRUG ABUSE RESEARCH CENTER IN MOLECULAR AND CELL BIOLOGY

分子和细胞生物学药物滥用研究中心

• 批准号: 6378773
• 负责人: HORACE LOH
• 金额: $ 92.25万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6378773
• 关键词: bioimaging /biomedical imaging; drug abuse; opioid receptor; pharmacology; receptor expression

In order to synchronize the two exiting program project grants, e propose to establish a Drug Abuse Research Center in Basic Molecular and Cell Biology at University of Minnesota which utilizes the expertise of the core faculty in the Department of Pharmacology and more effective promotes service and interaction with other drug abuse researchers in this community. During the past 8 years, we have proven that two P01 grants have worked successfully and coherently as a single program, with Horace H. Loh as the P.I. Thus, in the current proposal, we have combined various components from these two program projects to establish the proposed Drug Abuse Research Center. The main objectives of the proposed center are: (a) foster interdisciplinary approaches in drug abuse research among the investigators; (b) to serve as an "activity" center to coordinate and to promote all academic and scholarly activities in drug abuse research in the Minneapolis metropolitan area; (c) to serve as a national resource for molecular and cellular studies in the mechanisms of drug abuse either by providing expertise, reagents, clonal cell lines or transgenic/knockout animals to the drug abuse community locally and nationally; and (d) to serve as training center for young scientists here in Minnesota. Within the proposed center, there will be an Administration Core, a Molecular/Cellular and Genetic Core, an Antibodies Production Core and a Bioimaging Core which will support the activities of the scientific components. There are total 8 scientific components with 5 components which deal directly with the different aspects of the drug opiate, while the other three deals with other drugs of abuse, marijuana, nicotine and caffeine. All these 8 components deal with the investigation of the basic molecular and cell biological mechanisms of these drugs of abuse. The different approaches used: transgenic animals, molecular biological mutational analysis of proteins and genes, second messengers regulations, electrophysiological measurements and transcription control studies will provide a fertile ground for training of young scientists, interaction among investigators nd developing resource for the drug abuse research community locally and nationally.

为了同步两个现有计划项目拨款，e 建议 建立药物滥用基础分子与细胞研究中心 明尼苏达大学的生物学利用了 药理系核心师资力量更有效提升 在此方面的服务和与其他药物滥用研究人员的互动 社区。在过去的 8 年里，我们已经证明了两项 P01 资助 与霍勒斯（Horace）一起作为一个单独的项目成功而连贯地工作 H. Loh 饰 P.I.因此，在当前的提案中，我们结合了各种 这两个计划项目的组成部分旨在建立拟议的药物 虐待研究中心。拟议中心的主要目标是：(a) 促进药物滥用研究的跨学科方法 调查员； (b) 作为“活动”中心，协调和 促进药物滥用研究的所有学术和学术活动 明尼阿波利斯都会区； (c) 作为国家资源 药物滥用机制的分子和细胞研究 提供专业知识、试剂、克隆细胞系或转基因/基因敲除 当地和全国药物滥用社区的动物； (d) 至 作为明尼苏达州年轻科学家的培训中心。之内 拟议的中心，将有一个管理核心，一个 分子/细胞和遗传核心、抗体生产核心和 生物成像核心将支持科学活动 成分。共有 8 个科学组件，其中 5 个组件 直接涉及阿片类药物的不同方面，同时 另外三项涉及其他滥用药物、大麻、尼古丁和 咖啡因。所有这 8 个部分都涉及基本的调查 这些药物滥用的分子和细胞生物学机制。这 使用不同的方法：转基因动物、分子生物学 蛋白质和基因的突变分析，第二信使调控， 电生理测量和转录控制研究将 为青年科学家的培养、互动提供肥沃的土壤 调查人员之间并为药物滥用研究开发资源 当地和全国社区。