Vegf (in Situ Macular Edema & Uveitis

Vegf（原位黄斑水肿

• 批准号: 6507390
• 负责人: ROBERT B. NUSSENBLATT
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6507390
• 关键词: angiogenesis; blood; clinical research; diabetic retinopathy; edema; human tissue; immunopathology; plasma; protein biosynthesis; retina disorder; tocopherols; uveitis; vascular endothelial growth factors

Inreased intraocular and systemic levels of the angiogenic factor vascular endothelial growth factor (VEGF) is associated with new vessel growth in the eye, such as diabetic retinopathy. Recent work using immunopathologic techniques have shown that VEGF is upregulated in both experimentally induced uveitis and in uveitis eyes as well, with no evidence of neovascularization. This pilot study evaluated the level of VEGF in the blood of uveitic patients with and without cystoid macular edema. This level was determined also in the ocular fluid of those patietns undergoing ocular surgery. We measured the VEGF concentration in the aqueous humor of 20 uveitis patients (9 with and 11 without CME), and in the plasma of 40 uveitis patients (20 with and 20 without CME) and 20 healthy volunteers. Results: Mean aqueous humor VEGF concentrations for uveitis patients with and without CME were 152.3 and 109.5 pg/mL, p=0.048. Mean plasma VEGF concentrations in uveitis patients with and without CME and in healthy volunteers were 32.2, 29.6, and 55.0 pg/mL. Uveitis patients had lower plasma VEGF levels than healthy volunteers, p=0.002. Conclusions: VEGF concentration is elevated in the aqueous humor of uveitis patients with CME. Plasma VEGF concentration is reduced in uveitis patients on systemic immunosuppression. The VEGF antagonist Vitamin E will be investigated for the treatment of uveitis-associated CME.

血管生成因子血管内皮生长因子（VEGF）的眼内和全身水平与眼睛的新血管生长有关，例如糖尿病性视网膜病。使用免疫病理技术的最新工作表明，在实验性诱导的葡萄膜炎和葡萄膜炎眼中，VEGF均未上调，没有新的血管形成。这项初步研究评估了有或没有囊状黄斑水肿的葡萄膜患者血液中VEGF的水平。在那些接受眼科手术的pat的眼部液体中也确定了该水平。我们测量了20名葡萄膜炎患者的水性幽默的VEGF浓度（9例，无CME），以及40名葡萄膜炎患者的血浆（20例无CME）和20名健康志愿者。结果：有或没有CME的葡萄膜炎患者的平均幽默VEGF浓度为152.3和109.5 pg/ml，p = 0.048。有或没有CME的葡萄膜炎患者中的平均血浆VEGF浓度为32.2、29.6和55.0 pg/ml。葡萄膜炎患者的血浆VEGF水平低于健康志愿者，p = 0.002。结论：CME的葡萄膜炎患者的水性幽默升高VEGF浓度。在全身免疫抑制的葡萄膜炎患者中，血浆VEGF浓度降低。 VEGF拮抗剂维生素E将研究以治疗与葡萄膜炎相关的CME。