Assessment of human VOC exposure near Superfund sites

超级基金场地附近人体 VOC 暴露评估

• 批准号: 6443976
• 负责人: KARLA D THRALL
• 金额: $ 10.08万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443976
• 关键词: benzene; breath tests; chemical kinetics; chloroform; clinical research; environmental contamination; environmental exposure; environmental health; environmental toxicology; ethylenes; field study; hazardous substances; human subject; laboratory rat; model design /development; toluene; trichloroethylene; water supply

The research in this proposal to provide a fundamental understanding of the influence of route of reexposure on the total body burden and internal target tissue dosimetry of commonly encountered. Superfund contaminants, including trichloroethylene, perchloroethylene, 1,1- dichloroethylene, vinyl chloride, toluene, xylene, benzene, diethylbenzene isomers, and chloroform. Furthermore, since this research will involved extension of existing physiologically based pharmacokinetic models to describe the brain dosimetry following exposures, this effort will enhance the ability to accurately extrapolate animal studies to relevant human exposure scenarios and improve hazard and risk assessments. Exposure assessment studies will be conducted with human volunteers using a novel real-time breath analysis system to determine the uptake of any of the nine potential contaminants of study from tap water by each of three routes: inhalation, ingestion, and dermal contact. This data will be coupled with physiologically based pharmacokinetic (PBPK) modeling to determine the uptake kinetics and brain dosimetry. The resultant data from these comprehensive research projects within this Superfund program focused on development of biomarkers of susceptibility and response in potentially exposed populations. The specific research objectives are: 1. To generate physiologically based pharmacokinetic models to describe target organ dosimetry by route exposure. 2. To use the models to predict human dosimetry under environmentally relevant exposure conditions at characterized field study locations. 3. To conduct field studies to provide actual exposure assessments and target organ dose estimates by each route of exposure.

该提案中的研究旨在提供对重新曝光途径对常见的总体负担和内部目标组织剂量法的影响的基本理解。超级基金污染物，包括三氯乙烯，高氯乙烯，1,1-二氯乙烯，氯化乙烯基，甲苯，甲苯，二甲苯，苯，二乙基苯异构体和氯仿。此外，由于这项研究将涉及扩展现有的基于生理的药代动力学模型，以描述暴露后的大脑剂量测定法，因此这项工作将增强能够将动物研究准确推出动物研究到相关的人类暴露情况并改善危害和风险评估的能力。使用新型的实时呼气分析系统，将对人类志愿者进行暴露评估研究，以确定通过自来水中的每种途径中的每一种：吸入，摄入和真皮接触中的每一种。该数据将与基于生理的药代动力学（PBPK）建模相结合，以确定摄取动力学和脑剂量测定法。这些超级基金计划中这些综合研究项目的最终数据着重于开发潜在曝光人群中易感性和反应的生物标志物。具体的研究目标是：1。生成基于生理的药代动力学模型，以通过路线暴露来描述目标器官剂量测定。 2。使用模型预测在特征现场研究位置与环境相关的暴露条件下的人类剂量法。 3。进行现场研究以通过每种暴露途径提供实际的暴露评估和目标器官剂量估计。