MORPHOLOGICAL VARIABILITY MAPS IN SCHIZOPHRENIA

精神分裂症的形态变异图

• 批准号: 6477605
• 负责人: TONMOY SHARMA
• 金额: $ 4.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477605
• 关键词: bioimaging /biomedical imaging; biomedical resource; cognition; communication behavior; computers; magnetic resonance imaging; model design /development; nervous system; nuclear magnetic resonance spectroscopy; statistics /biometry

This proposal is part of a research program that aims to clarify (1) hemispheric specialization and independence. (2) interhemispheric spheric interaction, and (3) interhemispheric control. These mechanisms of interhemispheric relations address three central theoretical concepts in cognitive neuroscience: modularity of processing. intermodular communication. and behavior. Specific Aims A basic thesis of this research program is that the two cerebral hemispheres constitute parallel, semi-independent. information processing systems which interact through function-specific cortical channels in the corpus and through less specific subcortical channels. In the following proposal we analyze the anatomical basis of the relationship between hemispheric specialization and interhemispheric interaction by analyzing the anatomical substrates of language gifted asymmetric cortex and of the callosal channels that interconnect it. We focus on two regions corresponding to two of our main behavioral tasks; Broca's area, which is specialized for phonetic processing in dichotic listening to nonsense consonant-vowel syllables (CVs) and; Wernicke's area, which is specialized for lateralized lexical decision. Since we believe that the different behavioral measures draw upon these different cortical regions, we hypothesize that different behavioral measures will also be associated with different callosal channels. Furthermore, we expect the anatomical asymmetry of cortical modules will be negatively correlated with the size of the callosal channel that interconnects it. Another goal is to map the organization of callosal channels and their relationship to hemispheric specialization.

该建议是一项研究计划的一部分，旨在澄清 （1）半球专业和独立性。 （2）半球间 球形相互作用和（3）半球间对照。 这些 半球关系的机制解决了三个中心 认知神经科学中的理论概念： 加工。 跨沟通。 和行为。 具体目标 该研究计划的基本论文是两个脑 半球构成平行，半独立。 信息 通过功能特异性皮质相互作用的处理系统 语料库中的通道以及不太具体的皮层通道。 在以下提案中，我们分析了 半球专业和半球间的关系 通过分析有天赋的语言的解剖基质来进行互动 不对称皮层和互连的Callosal通道。 我们专注于与我们两个主要行为相对应的两个区域 任务； Broca的区域，专门用于语音处理 dichotic聆听胡说八道辅音音节（CVS）和； Wernicke的区域，专门用于侧向词汇 决定。 因为我们认为不同的行为措施借鉴了 这些不同的皮质区域，我们假设这是不同的 行为措施也将与不同的呼叫 频道。 此外，我们期望皮质的解剖学不对称 模块将与Callosos的大小负相关 频道将其互连。 另一个目标是映射 呼叫渠道的组织及其与 半球专业化。