CORE--HUMAN FRESH TISSUE BANK

核心--人体新鲜组织库

• 批准号: 6502910
• 负责人: BRITT-MARIE E. LJUNG
• 金额: $ 20.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6502910
• 关键词: biomedical facility; breast neoplasms; human subject; human tissue; tissue resource /registry

The tissue core will continue to provide all SPORE investigators with appropriate tissue. This will include archival and prospective formalin- fixed, paraffin-embedded, benign and malignant breast tissue from patients with and without diagnosis of breast cancer. A special effort will be done to identify benign and hyperplastic tissue in patients who subsequently developed breast cancer. In addition, initial and subsequent tissues from patients with carcinoma in situ who developed recurrent disease. Prospective fresh and frozen benign and malignant breast tissue, as well as skin from patients with new breast cancer, will be collected. We expect to continue to collect prospective fresh tissues at the current rate of about 100 cases per year. We expect to continue to identify archival paraffin embedded cases of benign tissue, hyperplasia, carcinoma in situ, as well as invasive cancers with the specific characteristics needed by the various research projects. Sources for tissues are California Pacific Medical Center (CPMC) and Aeron Laboratories. CPMC has a bank of about 14,000 benign and malignant archival cases and receives approximately 300 new breast cancers every year. Aeron Laboratories performs hormone receptor analyses on breast cancer specimens and has through Dr. Dollbaum, who is medical director, made surplus frozen material available from about 15,000 specimens. The tissue utilization committee will continue to consider requests both from SPORE projects and outside investigators.

组织芯将继续为所有孢子研究者提供 适当的组织。这将包括档案和前瞻性福尔马林 - 固定，石蜡包裹，良性和恶性乳房组织 有或没有诊断乳腺癌。将做出特别的努力 确定随后的患者的良性和增生组织 患上乳腺癌。另外，来自 癌症患者原位患有复发性疾病。 前瞻性新鲜和冷冻的良性和恶性乳腺组织 作为新乳腺癌患者的皮肤，将收集。我们期望 继续以目前的速度收集前瞻性新鲜组织 每年约100例。我们希望继续识别档案 良性组织，增生性，原位癌的石蜡嵌入病例， 以及具有具有特定特征的侵入性癌 各种研究项目。 组织的来源是加利福尼亚太平洋医疗中心（CPMC）和Aeron 实验室。 CPMC有大约14,000个良性和恶性的银行 档案案例，每次收到大约300个新的乳腺癌 年。 Aeron实验室对乳房进行激素受体分析 癌症标本，并通过医学总监Dollbaum博士拥有 使大约15,000个标本可提供盈余冷冻材料。这 组织利用委员会将继续考虑同时考虑的要求 孢子项目和外部调查人员。