SPECIALIZED CENTER OF RESEARCH IN HYPERBARIC OXYGEN THER

高压氧专业研究中心

• 批准号: 6375427
• 负责人: STEPHEN RAYMOND THOM
• 金额: $ 153.35万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-29 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6375427
• 关键词: alternative medicine; hyperbaric oxygen therapy

DESCRIPTION (Applicant's Abstract): This application is for a new program that represents a multidisciplinary effort to investigate the mechanisms of action, safety and clinical efficacy of Hyperbaric Oxygen (HB02) Therapy. HB02 herapy has been designated a complimentary or alternative modality by the National Center for Complementary and Alternative Medicine. This program consists of 4 Research Projects and 3 Support Cores which are centered on the hypothesis that: HB02 therapy will benefit head and neck cancer patients who must undergo reconstructive surgery after radiation therapy because, at pharmacological doses, oxygen augments angiogenesis and impedes specific types of intercellular adherence. Common themes within the four research projects are the biology and clinical responses to elevations in ambient 02 concentration of head and neck tumors, endothelium, macrophages and neutrophils. Project 1 will develop a predictive model for surgical risk among patients requiring laryngectomy due to cancer, validate the model and assess the efficacy of HB02 therapy for improving outcome. Stimulation of angiogenesis in irradiated tissue by HB02 is hypothesized in both Projects 1 and 2. Hypoxia and hypovascularity in both projects will be directly evaluated by histopathological analysis of biopsy samples and by a novel method, 02-dependent binding to tissues of the nitroimidazole compound EF-5. Project 2 will evaluate the mechanism for angiogenesis by HB02 in irradiated mice and tumor xenograft growth responses. Project 3 proposes that elevated partial pressures of 02 will reduce metastatic head and neck tumor cells and neutrophils from attaching to pulmonary endothelium. Project 4 proposes that HB02 increases the endogenous production of nitric oxide, a second messenger that, in turn, may play a role in many responses studied in this program. Scientific cores are Biostatistics and Data Management (Core B) and Chamber and High Pressure Equipment (Core C). The entire program will be supported by an administrative core (Core A). This coordinated program will provide new insights into mechanisms for HB02 and assess safety for clinical use.

描述（申请人的摘要）：此申请适用于新程序 这代表了研究机制的多学科努力 高压氧的作用，安全性和临床功效（HB02） 治疗。 HB02 Herapy已被指定为免费或替代方案 国家互补和替代医学中心的方式。 该计划由4个研究项目和3个支持核心组成 以这样的假设为中心：HB02治疗将使头颈癌受益 放射治疗后必须进行重建手术的患者 因为，在药理剂量时，氧气增强了血管生成并阻碍 特定类型的细胞间依从性。四个中的共同主题 研究项目是对海拔高度的生物学和临床反应 环境02头和颈部肿瘤的浓度，内皮，巨噬细胞和 中性粒细胞。项目1将开发一个预测性模型，以实现手术风险 需要因癌症而需要喉切除术的患者，验证模型并评估 HB02治疗改善预后的功效。刺激血管生成 在两个项目1和2中都假设在辐照组织中，HB02均假设缺氧。 两个项目的低血压将直接评估 活检样本和一种新方法的组织病理学分析， 02依赖于硝基咪唑化合物EF-5组织的结合。项目2 将评估HB02在辐照小鼠和 肿瘤异种移植生长反应。项目3提出了提升部分的提升 02的压力将减少转移性头部和颈部肿瘤细胞，以及 中性粒细胞从附着到肺部内皮。项目4提出 HB02增加了一氧化氮的内源产生，第二个使者 反过来，这可能在该程序中研究的许多响应中发挥作用。 科学核心是生物统计学和数据管理（核心B）和商会，以及 高压设备（Core C）。整个程序将由 管理核心（核心A）。该协调计划将提供新的 深入了解HB02的机制，并评估临床使用的安全性。