COMPENSATORY PLASTICITY RECOVERY OF FUNCTION AFTER MOTOR CORTICAL INJURY

运动皮质损伤后功能的代偿性可塑性恢复

• 批准号: 6564766
• 负责人: TERRY STANDFOR
• 金额: $ 19.74万
• 依托单位: WAKE FOREST UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564766
• 关键词: Macaca mulatta; behavior test; brain electrical activity; brain injury; disease /disorder model; electrodes; electromyography; electrostimulus; experimental brain lesion; eye movements; goal oriented behavior; hand; implant; limb movement; model design /development; motor cortex; neural plasticity; psychomotor function; restraint; stereotaxic techniques; stroke; visual stimulus

Using clinical cases of stroke models, one of the difficulties associated with evaluating the relationship between cortical damage/reorganization and functional deficit/recovery is the issue of variability. The patient population is heterogeneous with regard to both the amount and location of damaged cortical territory and, accordingly, the severity and type of physical impairment. This will also be true, albeit to a lesser extent, in non-human primate models of stroke. Project 4 proposes to use a focal lesion model of cortical reorganization, the specificity of which, will greatly aid our effort to reveal the fundamental principles of compensatory cortical plasticity. Specifically, our goal is to test specific hypotheses of cortical reorganization by ablating cortical regions that are important for motor control and by recording activity from those cortical regions that are likely to be compensatory during recovery of function. The relationship between plasticity and functional recovery are to be tested by combining focal lesions with targeted recording strategies, specific behavioral tasks, and readily quantifiable behavioral measures. The proposed experiments represents some of the earliest efforts to explore the relationship between cortical reorganization and recovery of function in this manner. In the short term, the specific approach will begin to unravel the complex relationships between damaged cortical territories, reorganizing cortical domains, and behavioral performance. In the long term, such knowledge should allow for more accurate prognoses and the design for rehabilitative strategies that are optimal for any given patter for cortical damage.

使用中风模型的临床病例，这是一个相关的困难之一 评估皮质损伤/重组之间的关系 功能不足/恢复是可变性的问题。病人 人口在数量和位置方面都是异质的 受损的皮质区域，因此，严重性和类型 身体障碍。这也将是正确的，尽管在较小程度上， 非人类的中风模型。项目4建议使用焦点 皮质重组的病变模型，其特异性将 极大地帮助我们揭示的基本原则 补偿性皮质可塑性。具体来说，我们的目标是测试 通过消融皮质进行皮质重组的特定假设 对于电机控制和记录活动很重要的区域 从那些可能是补偿性的皮质区域 恢复功能。可塑性与功能性之间的关系 应通过将局灶性病变与靶向的局灶性病变结合来测试恢复 记录策略，特定的行为任务和易于量化的 行为措施。提出的实验代表了一些 探索皮质之间关系的最早努力 以这种方式重组和恢复功能。在短期内 特定的方法将开始解开复杂的关系 在受损的皮质区域，重组皮质域和 行为表现。从长远来看，这种知识应该允许 更准确的预后和康复策略的设计 对于任何给定的皮质损伤，都是最佳的。