ANIT-INFLAMMATORY EFFECTS OF HUMAN MILK

母乳的抗炎作用

• 批准号: 6449029
• 负责人: E S BUESCHER
• 金额: $ 17.64万
• 依托单位: EASTERN VIRGINIA MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6449029
• 关键词: antiinflammatory agents; breast feeding; clinical research; colitis; colostrums; cytokine receptors; developmental nutrition; gastroenteritis; human milk; human subject; infant human (0-1 year); interleukin 1; laboratory rat; neutrophil; nutrition related tag; tumor necrosis factor alpha; urinalysis

This project proposes to evaluate the anti-inflammation effects of human milk feeding through free approaches: 1) Examination of human milk feeding effects and feeding of purified mil anti-inflammatory components on inflammation using animal models of inflammation; 2) in vitro studies of rat intestinal cell (target cell) and neutrophil (mediator cell) cellular responses to injury, and modulation of these responses by milk and milk anti-inflammatory components; 3) examination of the relationships between human milk content of anti-inflammatory components, urinary excretion of anti-inflammatory components by breast-fed infants and the degree of inflammation associated with illnesses in breast-fed infants. Each approach will emphasize the roles of the interleukin-1 receptor antagonist (IL-1RA) and soluble forms of the p55 and p75 TNFalpha receptors (sTNF RI and sTNF RII, respectively) in altering inflammatory responses following bowel injury (animal studies), and in the relationships between amounts fed, amounts excreted by the infant, and occurrence of illness. By defining these roles and relationships, we will establish a basis for progression to future studies examining infant feeding with formulas supplemented with anti-inflammatory components.

该项目建议评估人类的抗炎作用 通过免费方法喂养牛奶：1）检查人牛奶 喂养效果和纯化的MIL抗炎成分的喂养 使用炎症动物模型进行炎症； 2）体外研究 大鼠肠细胞（靶细胞）和中性粒细胞（介体细胞） 细胞对损伤的反应，并通过牛奶对这些反应进行调节 和牛奶抗炎成分； 3）关系检查 抗炎成分的人乳含量，尿 母乳喂养的婴儿和抗炎成分排泄 与母乳喂养的婴儿有关的炎症程度。 每种方法都会强调白介素-1受体的作用 p55和p75 tnfalpha的拮抗剂（IL-1RA）和可溶性形式 在改变炎症时，受体（分别为STNF RI和STNF RII） 肠损伤后的反应（动物研究）和 喂养的金额之间的关系，婴儿排泄的金额以及 疾病的发生。通过定义这些角色和关系，我们将 为未来研究婴儿的进展基础建立基础 用补充抗炎成分的配方喂养。