COMMUNITY BASED STUDY ON OCCUPATIONAL ASTHMA, ECRHS-OA

职业性哮喘社区研究，ECRHS-OA

• 批准号: 6390369
• 负责人: MANOLIS KOGEVINAS
• 金额: $ 13.44万
• 依托单位: MUNICIPAL INSTITUTE OF MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390369
• 关键词: Australia; British Isles; Europe; France; Germany; Italy; Scandinavian country; United States; asthma; atopy; blood chemistry; bronchus disorder; clinical research; diet; disease /disorder proneness /risk; dosage; dust; health care service utilization; human population study; human subject; immunoglobulin E; industry; interview; longitudinal human study; lung; nutrition related tag; occupational health /safety; occupations; questionnaires; respiratory disorder epidemiology; respiratory function; spirometry; tobacco abuse; work site; young adult human (21-34)

The overall aim of this large multicentre community based study of young men and women is to examine the occupations, industries and exposures in the work-place which are associated with a high risk for asthma and other adverse respiratory health effects, with particular emphasis on specific exposures of predominantly female occupations (irritants, detergents and other asthmagens), and of other high risk major occupations which have not been adequately examined. The main hypotheses of the study are that respiratory diseases are strongly related with exposure in the workplace, that a considerable proportion of adult onset asthma is associated with these exposures and that the importance of occupational risk factors for asthma has been underestimated, particularly among women. The occupational asthma study (ECRHS- OA) forms part of a wider international multicentre survey on respiratory health (European Community Respiratory Health Survey- ECRHS). The first phase of the ECRHS was conducted in 1991/92 and examined risk factors for asthma and atopy in subjects aged 20-44 years. The study is currently updated (ECRHS-II) following-up approximately 17,000 young adults from 12 countries (Australia, Belgium, France, Germany, Iceland, Italy, Norway, Spain, Sweden, Switzerland, UK and USA). Those subjects who took part in the first survey will be re-contacted in 1999, to determine risk factors for incidence and remission of asthma, other respiratory symptoms, atopy, changes in bronchial responsiveness and lung function. Subjects will be asked to perform a forced spirometry, methacholine challenge and to provide blood samples for IgE testing. A questionnaire administrated by trained interviewers will be delivered requesting information on respiratory symptoms and diseases, socio-demographic factors, tobacco smoking, complete occupational history since the last survey, environmental exposures, family history, diet, treatment and use of health services. Modular occupational questionnaires will be developed for subjects employed as cleaners, homemakers, welders, metal workers, nurses, and subjects exposed to organic dusts in the paper and textile industries. The study will provide valid and precise estimates on the importance of specific occupations, industries and exposures in relation to asthma incidence and prevalence, similar estimates for other respiratory symptoms and diseases and also for declines in pulmonary function.

这项针对年轻男性和女性的大型多中心社区研究的总体目标是检查与哮喘和其他不良呼吸系统健康影响高风险相关的职业、行业和工作场所接触情况，特别强调特定的主要是女性职业（刺激物、清洁剂和其他哮喘原）以及其他尚未得到充分检查的高风险主要职业的暴露。 该研究的主要假设是，呼吸系统疾病与工作场所的暴露密切相关，相当大比例的成人哮喘发病与这些暴露有关，并且职业危险因素对哮喘的重要性被低估，特别是在女性中。 职业性哮喘研究 (ECRHS-OA) 是更广泛的国际多中心呼吸健康调查（欧洲社区呼吸健康调查 - ECRHS）的一部分。 ECRHS 的第一阶段于 1991/92 年进行，检查了 20-44 岁受试者的哮喘和特应性危险因素。 该研究目前正在更新 (ECRHS-II)，对来自 12 个国家（澳大利亚、比利时、法国、德国、冰岛、意大利、挪威、西班牙、瑞典、瑞士、英国和美国）的约 17,000 名年轻人进行了随访。 那些参加第一次调查的受试者将在 1999 年再次联系，以确定哮喘、其他呼吸道症状、特应性、支气管反应性和肺功能变化的发病和缓解的危险因素。 受试者将被要求进行强制肺活量测定、乙酰甲胆碱激发并提供用于 IgE 测试的血液样本。 将由经过培训的采访员进行调查问卷，要求提供有关呼吸道症状和疾病、社会人口因素、吸烟、自上次调查以来的完整职业史、环境暴露、家族史、饮食、治疗和卫生服务使用的信息。 将为清洁工、家庭主妇、焊工、金属工人、护士以及造纸和纺织工业中接触有机粉尘的受试者开发模块化职业问卷。 该研究将对特定职业、行业和接触对哮喘发病率和患病率的重要性提供有效和精确的估计，对其他呼吸道症状和疾病以及肺功能下降也提供类似的估计。

项目成果

Employment status and use of respiratory protection among metalworkers, solderers and welders.

金属工人、焊工和电焊工的就业状况和呼吸防护装置的使用。

• 发表时间: 2007-08
• 影响因子: 4.9
• 作者: Mirabelli, Maria C;Zock, Jan;Plana, Estel;Benke, Geza;Kromhout, Hans;Norback, Dan;Olivieri, Mario;Radon, Katja;Villani, Simona;Kogevinas, Manolis
• 通讯作者: Kogevinas, Manolis

Reference values of total serum IgE and their significance in the diagnosis of allergy in young European adults.

欧洲年轻人血清总 IgE 的参考值及其在过敏诊断中的意义。

• 发表时间: 2007
• 影响因子: 2.8
• 作者: Carosso, Aurelia;Bugiani, Massimiliano;Migliore, Enrica;Anto, Josep Maria;DeMarco, Roberto
• 通讯作者: DeMarco, Roberto

Occupational risk factors for asthma among nurses and related healthcare professionals in an international study.

一项国际研究中护士和相关医疗保健专业人员哮喘的职业危险因素。

• 发表时间: 2007-07
• 影响因子: 4.9
• 作者: Mirabelli, Maria C;Zock, Jan;Plana, Estel;Anto, Josep Maria;Benke, Geza;Blanc, Paul D;Dahlman;Jarvis, Deborah L;Kromhout, Hans;Lillienberg, Linnea;Norback, Dan;Olivieri, Mario;Radon, Katja;Sunyer, Jordi;Toren, Kjell;van S
• 通讯作者: van S

Comparison of self-reported occupational exposure with a job exposure matrix in an international community-based study on asthma.

在一项基于国际社区的哮喘研究中，自我报告的职业暴露与工作暴露矩阵的比较。

• 发表时间: 2005-05
• 影响因子: 3.5
• 作者: de Vocht, Frank;Zock, Jan;Kromhout, Hans;Sunyer, Jordi;Antó, Josep M;Burney, Peter;Kogevinas, Manolis
• 通讯作者: Kogevinas, Manolis

Association between modelled traffic-related air pollution and asthma score in the ECRHS.

ECRHS 中模拟交通相关空气污染与哮喘评分之间的关​​联。

• 发表时间: 2009-10
• 作者: Jacquemin, B;Sunyer, J;Forsberg, B;Aguilera, I;Bouso, L;Briggs, D;de Marco, R;Garcia;Heinrich, J;Jarvis, D;Maldonado, J A;Payo, F;Rage, E;Vienneau, D;Kunzli, N
• 通讯作者: Kunzli, N