NONLINEAR MODEL OF HIPPOCAMPUS

海马体非线性模型

• 批准号: 6480873
• 负责人: THEODORE W BERGER
• 金额: $ 15.58万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480873
• 关键词: bioengineering /biomedical engineering; biomedical resource; drug adverse effect; ear; nervous system; statistics /biometry

The importance of the vestibulo-ocular reflex (VOR) for stabilizing vision during active movements is generally unrecognized, until pathology impairs VOR performance sufficiently to interfere with dynamic visual acuity. We have developed VOR modeling techniques that allow clinicians to evaluate patients VOR function objectively. During the past year, we extended these modeling techniques to include objective monitoring during therapy. We introduced a new measure of "super performance" based on athletes' abilities to improve their dynamic visual acuity through exercise therapy. By modeling their VORs during therapy, we are able to monitor and predict improvements in dynamic visual acuity during athletic performance. Mild head injury during sports performance often shows up as decreased visual stabilization by the VOR. Two professional football tams are currently being tested with our modeling techniques. In addition, the University of Virginia conducted a study of 100 athletes, using our VOR modeling techniques. A doctoral thesis in Exercise Physiology at that university is based on re-testing the VORs of a subset of these athletes after mild head injury. We extended our analysis of the broad-band characteristics of the VOR to studies of human subjects during walking/running. The preliminary results describe an important new role for lower-frequency channels of the VOR, that we anticipate will lead to focused therapy for preventing falls in the elderly.

前庭 - 眼反射（VOR）的重要性 在主动运动过程中稳定视力通常未被认可， 直到病理损害VOR性能足以干扰 动态视力。 我们已经开发了建模技术 允许临床医生客观地评估患者的功能。 在过去的一年中，我们将这些建模技术扩展到包括 治疗过程中的客观监测。 我们介绍了一种新的措施 基于运动员改善他们的能力的“超级表现” 通过运动疗法动态视力。 通过建模 在治疗期间，我们能够监视和预测改进 在运动表现过程中动态视力。 轻度头 运动表现期间的伤害通常会随着视觉降低而出现 VOR稳定。 两个职业足球tam是 目前正在使用我们的建模技术进行测试。 另外， 弗吉尼亚大学对100名运动员进行了研究，使用我们 VOR建模技术。 运动生理学的博士学位论文 该大学是基于重新测试其中一部分的VOR 轻度头部受伤后的运动员。 我们扩展了对 对人类受试者的研究的宽带特征 在步行/跑步期间。 初步结果描述了一个重要的 我们期望VOR的低频渠道的新角色 将导致重点疗法防止老年人跌倒。