NONLINEAR MODEL OF HIPPOCAMPUS

海马体非线性模型

• 批准号: 6480873
• 负责人: THEODORE W BERGER
• 金额: $ 15.58万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480873
• 关键词: bioengineering /biomedical engineering; biomedical resource; drug adverse effect; ear; nervous system; statistics /biometry

The importance of the vestibulo-ocular reflex (VOR) for stabilizing vision during active movements is generally unrecognized, until pathology impairs VOR performance sufficiently to interfere with dynamic visual acuity. We have developed VOR modeling techniques that allow clinicians to evaluate patients VOR function objectively. During the past year, we extended these modeling techniques to include objective monitoring during therapy. We introduced a new measure of "super performance" based on athletes' abilities to improve their dynamic visual acuity through exercise therapy. By modeling their VORs during therapy, we are able to monitor and predict improvements in dynamic visual acuity during athletic performance. Mild head injury during sports performance often shows up as decreased visual stabilization by the VOR. Two professional football tams are currently being tested with our modeling techniques. In addition, the University of Virginia conducted a study of 100 athletes, using our VOR modeling techniques. A doctoral thesis in Exercise Physiology at that university is based on re-testing the VORs of a subset of these athletes after mild head injury. We extended our analysis of the broad-band characteristics of the VOR to studies of human subjects during walking/running. The preliminary results describe an important new role for lower-frequency channels of the VOR, that we anticipate will lead to focused therapy for preventing falls in the elderly.

前庭眼反射 (VOR) 的重要性 在主动运动期间稳定视力通常未被认识到， 直到病理损害 VOR 性能足以干扰 动态视力。 我们开发了 VOR 建模技术 允许临床医生客观地评估患者的 VOR 功能。 在过去的一年里，我们扩展了这些建模技术，包括 治疗期间进行客观监测。 我们推出了一项新措施 “超级表现”基于运动员的能力来提高他们的能力 通过运动疗法提高动态视力。 通过建模他们的 治疗期间的 VOR，我们能够监测和预测改善情况 运动表现期间的动态视力。 轻度头 运动过程中的损伤通常表现为视力下降 VOR 稳定。 两名职业足球运动员是 目前正在使用我们的建模技术进行测试。 此外， 弗吉尼亚大学对 100 名运动员进行了一项研究，使用我们的 VOR 建模技术。 运动生理学博士论文 该大学基于重新测试其中一部分的 VOR 轻度头部受伤后的运动员。 我们扩展了对 VOR 的宽带特性对人类受试者的研究 步行/跑步期间。 初步结果描述了一个重要的 我们预计 VOR 低频信道的新作用 将导致针对预防老年人跌倒的集中治疗。