CORE--IMAGING

核心--成像

• 批准号: 6478911
• 负责人: ANNA-LIISA BROWNELL
• 金额: $ 5.36万
• 依托单位: MCLEAN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478911
• 关键词: Macaca fascicularis; Parkinson's disease; behavior test; bioimaging /biomedical imaging; biomedical facility; brain circulation; brain imaging /visualization /scanning; brain metabolism; chordate locomotion; dopamine receptor; human fetus tissue; magnetic resonance imaging; positron emission tomography; postmortem

The purpose of the imaging core is to support Projects 1, 2 and 3 for the experimental research studies proposed in this Parkinson's disease 9PD) Research Center program. Specific activities of the core are: 1) To provide all MRI, MRS and PET studies for pre- and post-operative experiments of all parkinsonian MPTP monkeys. 2) To provide in vivo monitoring for the progressive development of PD in primates and the neuroprotection provided by the interventions listed in Project 1. The dopamine synapse loss index curves derived by PET from the current animal models (see preliminary data) will allow an investigation of such neuroprotective or restorative interventions, mainly through the use of radioactively labeled CFT (dopamine reuptake sites) and MRS studies of neurochemicals. 3) To provide physiological information of cerebral hemodynamics, glucose metabolism and dopaminergic function that different transplantation protocols into striatum, substantia nigra and subthalamic nucleus using and human fetal cells (Project 2.) And stem cells (PROJECT 3.) to examine motor circuitry based on dopaminergic reinnervation. 4) To enable research fellows to train in neural imaging techniques and technology for PD. The combined PET and MRI core facility provides an educational environment for fellows in which a large database can be compared to the experimental animals planned. The usefulness and application of these methods also allow a comparative data set to the MGH/McLean and HARVARD Primate Center facilities. Novel experiments and training opportunities are therefore abundant.

成像核心的目的是支持项目 1、2 和 3，用于帕金森病 9PD) 研究中心计划中提出的实验研究。核心的具体活动是： 1) 为所有帕金森病 MPTP 猴子的术前和术后实验提供所有 MRI、MRS 和 PET 研究。 2) 为灵长类动物帕金森病的进展以及项目 1 中列出的干预措施提供的神经保护提供体内监测。通过 PET 从当前动物模型中得出的多巴胺突触损失指数曲线（参见初步数据）将允许进行调查这种神经保护或恢复性干预措施的研究，主要是通过使用放射性标记的 CFT（多巴胺再摄取位点）和神经化学物质的 MRS 研究。 3) 提供脑血流动力学、葡萄糖代谢和多巴胺能功能的生理信息，使用不同的移植方案进入纹状体、黑质和丘脑底核，并使用人类胎儿细胞（项目2.）和干细胞（项目3.）来检查基于运动回路的关于多巴胺能神经支配。 4) 使研究人员能够接受神经成像技术和PD技术的培训。 PET 和 MRI 相结合的核心设施为研究员提供了一个教育环境，其中可以将大型数据库与计划的实验动物进行比较。这些方法的实用性和应用还允许对 MGH/McLean 和哈佛灵长类动物中心设施进行比较数据集。因此，新颖的实验和培训机会非常丰富。