Effects of Increased Endolymph Volume on Cochlear and Vestibular Function and Morphology of Inner Ear Tissues

内淋巴量增加对耳蜗和前庭功能以及内耳组织形态的影响

• 批准号: nhmrc : 1044219
• 负责人: Dr Daniel Brown
• 金额: $ 20.9万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effects-increased-endolymph-ear-tissues/111642
• 关键词: Effects; Increased; Endolymph; Volume; Cochlear

Our recent research suggests that the vertigo attacks associated with enlarged fluid volumes in the inner ear, in diseases such as Ménière's Disease, maybe triggered when the fluid pressure forces open tissue valves located in the fluid-ducts connecting the hearing and balance organs. This project aims to identify the functional role of these valves, and to develop an animal model of abrupt changes in vestibular activity due to hydrops, to allow future treatments to be developed.

我们最近的研究表明，在梅尼埃病等疾病中，当流体压力迫使位于连接听觉和平衡器官的流体管道中的组织瓣膜打开时，可能会引发与内耳液体积增大相关的眩晕发作。旨在确定这些瓣膜的功能作用，并开发因积水导致前庭活动突然变化的动物模型，以便开发未来的治疗方法。