Exercise & influenza immunity:Psychoneuroendocrine Model

锻炼

• 批准号: 6471076
• 负责人: Marian L Kohut
• 金额: $ 32.33万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6471076
• 关键词: beta adrenergic receptor; catecholamines; cell proliferation; clinical research; cytokine; cytotoxic T lymphocyte; exercise; helper T lymphocyte; human old age (65+); human subject; immunity; immunization; immunoglobulin G; immunoregulation; influenza; inhibitor /antagonist; neuroendocrine system; psychological stressor

DESCRIPTION (provided by applicant): The purpose of the proposed study is to investigate the effects of a regular, moderate exercise program on the immune response to influenza immunization in older adults; and to determine whether the mechanisms of the exercise-induced immunomodulation involve psychosocial and/or neuroendocrine adaptations. Older adults experience a greater incidence and severity of influenza infection, as well as reduced vaccine efficacy. We hypothesize that exercise will enhance immune response to the vaccine and improve psychosocial state. A total of 72 men and women > age 65 will be assigned to an exercise (EX), n=36, or control (CON) group, n=36. An additional 32 subjects (n= 16 EX, n=16 CON) currently treated with non-selective beta-adrenergic receptor antagonists will be recruited to test the hypothesis that the immunomodulatory effects of exercise are mediated via catecholamine activation of beta-adrenergic receptors. Subjects will be immunized with influenza vaccine and will be randomly assigned to participate in either a regular vigorous aerobic exercise program (EX) or a flexibility program (CON) for one year. Blood samples will be taken pre and post-immunization. At the end of one year, subjects will be immunized again and blood samples will be taken pre-immunization and up to 6 months post-immunization. Psychosocial measures of depression, perceived stress, social support, positive/negative affect, and daily hassles/uplifts will be assessed numerous times throughout the study. The primary immune outcome measures are: anti-influenza IgG and IgG1, influenza specific peripheral blood mononuclear cell proliferation and cytokine (interleukin (lL)-2, IL-10, interferon (IFN)-gamma) production, cytotoxic T lymphocyte (CTL) function, and intracellular influenza-specific IL-2, IL-b 0, IFN-gamma, in CD4+, CD8+, CD45RA+ and CD45RO+ cells. Growth curve modeling will be used to analyze the relationship between treatment condition and changes in the measures of immunocompetence over time. The findings from this study may have relevance from both a clinical and basic research perspective, if moderate exercise is associated with enhanced anti-influenza immunity and improved protection from infection.

描述（由申请人提供）：拟议研究的目的是 研究定期、适度的运动计划对免疫系统的影响 老年人对流感免疫的反应；并确定是否 运动引起的免疫调节机制涉及社会心理 和/或神经内分泌适应。老年人的发病率更高 和流感感染的严重程度，以及疫苗功效的降低。我们 假设运动会增强对疫苗的免疫反应，并且 改善社会心理状态。共有 72 名年龄 > 65 岁的男性和女性将参加 分配给练习组 (EX)，n=36，或控制组 (CON)，n=36。额外的 32 名受试者（n= 16 EX，n=16 CON）目前接受非选择性治疗 将招募β-肾上腺素能受体拮抗剂来检验这一假设 运动的免疫调节作用是通过儿茶酚胺介导的 β-肾上腺素能受体的激活。受试者将接受免疫接种 流感疫苗，并将被随机分配参加 定期剧烈有氧运动计划 (EX) 或灵活性计划 (CON) 一年。将在免疫前和免疫后采集血样。在最后 一年后，受试者将再次免疫并采集血液样本 免疫前和免疫后 6 个月内。心理社会测量 抑郁、感知压力、社会支持、积极/消极影响，以及 在整个研究过程中，每天的麻烦/提升将被多次评估。这 主要免疫结果指标为：抗流感 IgG 和 IgG1、流感 特异性外周血单个核细胞增殖和细胞因子 （白介素 (lL)-2、IL-10、干扰素 (IFN)-gamma）产生、细胞毒性 T 淋巴细胞 (CTL) 功能和细胞内流感特异性 IL-2、IL-b 0、 CD4+、CD8+、CD45RA+ 和 CD45RO+ 细胞中的 IFN-γ。生长曲线建模将 用于分析治疗条件与变化之间的关系 随着时间的推移免疫能力的测量。这项研究的结果可能 从临床和基础研究的角度来看都具有相关性（如果中等） 运动与增强抗流感免疫力和改善免疫力有关 防止感染。