Simulation Modeling of Colorectal Cancer

结直肠癌的仿真建模

• 批准号: 6479142
• 负责人: ROBERT Steven DITTUS
• 金额: $ 34.86万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-15 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6479142
• 关键词: adenoma; cancer information system; cancer risk; colorectal neoplasms; computer assisted diagnosis; computer human interaction; computer program /software; computer simulation; computer system design /evaluation; cost effectiveness; endoscopy; gastrointestinal imaging /visualization; health behavior; mass screening; mathematical model; model design /development

DESCRIPTION: The goals of this research are to build a new and more powerful discrete-event simulation model based on an existing, validated computer model of the natural history of colorectal neoplasia and use the new model to address questions concerning the clinical outcomes, cost, effectiveness, cost- effectiveness, and resource utilization of various colorectal cancer (CRC) control strategies for patients and for complex and dynamic populations. These goal will be achieved through the translation of an existing model into C++, an object-oriented programming language that would improve the model's ease of modification, decrease the time needed to complete an analysis, and allow direct interaction between the model and other commonly available programming applications. The new model will be programmed to allow the simulation of populations whose individual members are characterized by multiple and interacting cancer risk factors, have varying degrees of adherence with established cancer control protocols, and receive their care in settings where the resources needed to provide cancer control interventions are limited. The parameterization of this model will be based on a rigorous review of the literature and the model will be validated by several methods, including existing cancer control outcome data. After completion of its programming, parameterization and validation, the applicant will demonstrate the power and versatility of this new computer model by employing it in various complex analyses concerning the expected outcome over time of implementing new cancer control strategies in both the general U.S. population and specific subpopulations representing relevant geopolitical and payer/provider groupings. In addition, the applicant will examine the impact of resource constraints (such as manpower) on the outcomes of proposed cancer control strategies and the implications of disparities in such resources across geopolitical boundaries and healthcare provider markets. The completed model will be able to predict the outcomes of any given CRC control strategy, among specific risk-defined patient subgroups, in any given population, during and over any period of time. This model could serve as a template and modeling paradigm for the examination of the cost-effectiveness of prevention and treatment strategies for other cancers and for diseases other than cancer.

描述：这项研究的目标是建立一个新的，更强大的 基于现有的，经过验证的计算机模型的离散事件仿真模型 结直肠肿瘤的自然历史，并使用新模型 解决有关临床结果，成本，有效性，成本 - 的问题 各种大肠癌（CRC）的有效性和资源利用 控制患者以及复杂和动态人群的策略。 这些目标将通过将现有模型转换为 C ++，一种面向对象的编程语言，可以改善模型的 易于修改，减少完成分析所需的时间以及 允许模型与其他常用的其他相互作用 编程应用程序。 新模型将被编程，以允许 模拟其个人成员的特征的人群的模拟 多种且相互作用的癌症风险因素具有不同程度的 遵守既定的癌症控制方案，并在 提供癌症控制干预措施所需的资源的设置 有限。 该模型的参数化将基于严格 文献和模型的审查将通过多种方法验证， 包括现有的癌症控制结果数据。 完成后 编程，参数化和验证，申请人将演示 该新计算机模型的功能和多功能性通过在 随着时间的推移，有关预期结果的各种复杂分析 在美国普通人群中实施新的癌症控制策略 以及代表相关地缘政治和 付款人/提供商分组。 此外，申请人将检查影响 关于拟议癌症结果的资源限制（例如人力） 控制策略及其在此类资源中的含义 跨地缘政治边界和医疗保健提供者市场。 完整的 模型将能够预测任何给定的CRC控制策略的结果， 在特定风险定义的患者亚组中，在任何给定的人群中， 并在任何一段时间内。 该模型可以用作模板，并且 建模范式检查预防成本效益 以及其他癌症和癌症以外的疾病的治疗策略。