TRAINING IN TRAUMA AND SEPSIS RESEARCH

创伤和脓毒症研究培训

• 批准号: 6351089
• 负责人: RICHARD L. SIMMONS
• 金额: $ 23.81万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6351089
• 关键词: TRAINING; TRAUMA; SEPSIS; RESEARCH; TRAINING; TRAUMA; SEPSIS; RESEARCH

This postdoctoral training program proposal is designed to train fellows, principally surgeons, for a period of two-to-three years each, in basic science research relevant to trauma and sepsis. Funds to support a total of five positions each year (two new fellows each year, two second year positions, and one third-year) are requested. The overall research focus of the trainees is the molecular biology of the inflammatory response to injury. Three areas of research have been targeted: I) The molecular biology of hemorrhagic and traumatic shock; II) The regulation and function of nitric oxide in sepsis and trauma; and III) Mechanisms of immunoregulation in surgical patients. These areas coincide with current extramural research grants on which the faculty collaborate. The research plans are superb vehicles for training because they ask broad questions on which precise, well-targeted individual research training efforts can be staged. The faculty is highly qualified, and all principle trainers have extramural research support and much training experience. Upon completion of the training program the fellow will understand how to design, carry out, and complete experiments to answer discrete biological questions derived from trauma victims and septic patients. The fellow will thus be trained, not simply in the sophisticated laboratory methodology in molecular biology, biochemistry, and cellular immunology, but also in the though processes to apply to future experimental problems. All trainees will have the opportunity to take formal academic courses offered by the basic science departments of the University of Pittsburgh and some will complete PhDs in the basic science departments. Most training will take place in the laboratories of the principle trainers who are all extramural grant-funded senior scientists in the areas of molecular biology, biochemistry, immunology, and cell biology, using a carefully though-out and well-proven modification of the master/apprentice system. The central training technique combines weekly one-on-one meetings between the apprentice and the trainer plus hour- long research training seminars twice weekly at which supervision subcommittees of four or five trainers, whose special skills supplement the friendly collaborative research and training simultaneously. The individual fellows choose a principle trainer and the Executive Training Committee tailors a fellowship supervising committee of faculty co- trainers to provide expert training necessary to supplement the talents of the principal trainer. Affirmative action recruitment efforts have already been very successful, and will continue; the training facilities can serve more fellows than will be funded by this training proposal. All the training can be carried out in the more than 50,000 square feet of fully equipped laboratory space available.

在与创伤和败血症有关的基础科学研究中，这项博士后培训计划的建议旨在培训培训研究员，主要是外科医生两到三年。要求每年支持五个职位的资金（每年有两个新的研究员，两个第二年职位和三年级）。学员的总体研究重点是炎症对损伤的分子生物学。研究的三个领域是针对的：i）出血和创伤性休克的分子生物学； ii）一氧化氮在败血症和创伤中的调节和功能； iii）手术患者免疫调节的机制。这些领域与当前教师合作的当前校外研究补助金一致。该研究计划是训练的精湛工具，因为他们提出了有关可以上演哪些精确，精心定位的个人研究培训工作的广泛问题。该教师具有很高的资格，所有主要培训师都具有校外研究的支持和大量的培训经验。培训计划完成后，研究员将了解如何设计，进行和完成实验，以回答从创伤受害者和化粪池患者中得出的离散生物学问题。因此，该研究员将受到培训，而不仅仅是在分子生物学，生物化学和细胞免疫学方面的复杂实验室方法中进行培训，还可以在适用于未来的实验问题的过程中进行培训。所有学员将有机会参加匹兹堡大学基础科学系提供的正式学术课程，其中一些人将在基础科学系完成博士学位。大多数培训都将在主要培训师的实验室中进行，他们都是分子生物学，生物化学，免疫学和细胞生物学领域的校外资助的高级科学家，使用了良好的和精心培训的主体/学徒系统的修改。中央培训技术结合了学徒与培训师之间的每周一对一会议，以及每周两次的研究培训研讨会，在该研讨会上进行了两次监督小组委员会的四到五名培训师，他们的特殊技能补充了友好的协作研究和同时的培训。个人研究员选择一名主要培训师，执行培训委员会为教职员工培训师的奖学金监督委员会量身定制，以提供必要的专家培训，以补充主要培训师的才能。平权行动招聘工作已经非常成功，并且将继续；培训设施可以提供比该培训建议所资助的更多研究员。所有培训都可以在可用的超过50,000平方英尺的实验室空间中进行。