Metabolic and hemodynamic sensor for monitoring throughout the continuum of care

用于在整个护理过程中进行监测的代谢和血流动力学传感器

基本信息

项目摘要

Project Summary This project will develop a wearable continuous monitor for reporting and predicting physiological state during trauma, shock and sepsis with the goal of predicting morbidity, mortality, and providing feedback during medical intervention. I can also be used as a triage tool. The proposed technology responds to technology gaps published by the Department of Defense Combat Casualty Care Research Program and an NIH Notice of Special Interest in Physiological Monitoring and Point of Care Technologies for Trauma Care. The hybrid technology has an ultra- thin flexible multiple analyte sensor placed just under the skin attached to a flexible wearable patch for non- invasive hemodynamic monitoring. Together these technologies provide real time monitoring of blood oxygenation, heart rate, lactate, tissue oxygen, glucose, and pH. In Aim 1 we will design and construct a minimally invasive continuous sensor for glucose, lactate, oxygen and pH. It has been shown that frequent monitoring of these analytes not only identifies risk at initial injury, but can predict morbidity and outcomes, guide intervention, and stratify medical conditions associated with trauma that may have overlapping or cryptic symptoms. In Aim 2 we will design and construct a wearable patch that operates the sensor developed in Aim1 and further includes the non-invasive technology of pulse oximetry, autonomous operation, and wireless telemetry. The wearable and sensor are both made of flexible circuits providing comfort and mechanical matching of the indwelling component, and conformal attachment of the wearable to the skin. In Aim 3 we will conduct a study using a porcine model of hemorrhagic injury and sensor-guided resuscitation. At the completion of the grant, we will have a validated monitoring technology and can begin the process of applying for an Investigational Device Exemption from the FDA to proceed to human studies.
项目摘要 该项目将开发可穿戴的连续监视器,用于报告和预测生理状态 创伤,震动和败血症的目的是预测医疗期间的发病率,死亡率并提供反馈 干涉。我也可以用作分类工具。拟议的技术应对发布的技术差距 国防部战斗人员伤亡护理研究计划和NIH特别关注的通知 在生理监测和护理技术的创伤护理技术中。混合技术具有超级 纤维柔性多个分析物传感器放置在皮肤附近的柔性可穿戴贴片上,用于非 - 侵入性血液动力学监测。这些技术一起提供了对血液的实时监测 氧合,心率,乳酸,组织氧,葡萄糖和pH。在AIM 1中,我们将设计和构建一个 葡萄糖,乳酸,氧和pH的微创连续传感器。已经证明了频繁的 监测这些分析物不仅可以识别最初受伤时的风险,而且可以预测发病率和结果 干预,并分层与可能重叠或神秘的创伤相关的医疗状况 症状。在AIM 2中,我们将设计和构建一个可穿戴贴片,该贴片运行AIM1中开发的传感器 进一步包括脉搏血氧饱和度,自主操作和无线的非侵入性技术 遥测。可穿戴和传感器都是由柔性电路制成的,可提供舒适性和机械性 匹配的留置组件以及可穿戴型皮肤的共形附件。在目标3中,我们将 使用出血性损伤和传感器引导复苏的猪模型进行研究。完成 在赠款中,我们将拥有经过验证的监视技术,并可以开始申请 调查设备免于FDA进行人类研究。

项目成果

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Elliot Lawrence Botvinick其他文献

Elliot Lawrence Botvinick的其他文献

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{{ truncateString('Elliot Lawrence Botvinick', 18)}}的其他基金

3D TRACKING OF FIBRIN FIBERS
纤维蛋白纤维的 3D 追踪
  • 批准号:
    8365778
  • 财政年份:
    2011
  • 资助金额:
    $ 61.32万
  • 项目类别:
INGTEGRATING BIOMATERIALS & BIOPHOTONICS TO ASSESS ECM MECHANICS
整合生物材料
  • 批准号:
    8170961
  • 财政年份:
    2010
  • 资助金额:
    $ 61.32万
  • 项目类别:
INGTEGRATING BIOMATERIALS & BIOPHOTONICS TO ASSESS ECM MECHANICS
整合生物材料
  • 批准号:
    7956525
  • 财政年份:
    2009
  • 资助金额:
    $ 61.32万
  • 项目类别:

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