AUDITORY PROCESSING IN BRAINSTEM

脑干的听觉处理

基本信息

批准号：
6379266
负责人：
JOSEPH A SISNEROS
金额：
$ 4.02万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-06-01 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/6379266
关键词：
Osteichthyes acoustic nerve afferent nerve auditory nuclei auditory stimulus biological signal transduction brain stem labyrinth medulla oblongata neural information processing neuroanatomy neurons neurophysiology otocyst /otolith social behavior vocalization

项目摘要

This proposed study will investigate the functional organization of the central auditory system in the brainstem of a vocal fish, the plainfin midshipman (Porichthys notatus). Vocalizing species, including humans, are faced with the fundamental problem of segregating concurrent vocal signals during social communication. Recent studies in the midshipman have revealed insights into the neural mechanisms that underlie vocal signal segregation. Specific aims are to: (1) use neuroanatomical methods to determine the central projections to the medulla of physiologically identified afferents from inner ear otolithic endorgans that may serve an acoustic function, (2) characterize the response properties of medullary auditory neurons to individual and concurrent social acoustic signals that mimic natural vocalizations using standard extracellular recording techniques, and (3) use neuroanatomical methods coupled with neurobiotin injections and extra-and intracellular recording techniques to identify the central projections of physiologically-characterized medullary auditory neurons to the midbrain and other brainstem auditory nuclei. This proposed study will determine how the midshipman auditory brainstem processes biologically meaningful stimuli and may provide novel information of how individual and concurrent signals, such as vowels in human speech, are coded and segregated within the vertebrate auditory system.

这项拟议的研究将调查中央听觉系统的功能组织，在声带的脑干，Plainfin Midshipman（Porichthys Notatus）。包括人类在内的发声物种面临着在社交交流过程中隔离并发声音的基本问题。在中级船员的最新研究揭示了对源自人声信号隔离的神经机制的见解。具体目的是：（1）使用神经解剖学方法来确定来自内耳耳原石内虫的生理鉴定传入的髓质的中心投影，这些传入可能具有声学功能，（2）表征了甲麦中的响应特性社交声学信号，使用标准细胞外记录技术模仿自然发声，（3）使用神经解剖学方法以及神经生素注射和细胞内记录技术的结合，以确定生理特征的冥想式听觉式听觉脑中的中心预测核。这项拟议的研究将确定Midshipman听觉脑干过程如何生物学上有意义的刺激，并可能提供有关如何在脊椎动物听觉系统中对个人和并发信号（例如人类言语中的元音）进行编码和隔离的新颖信息。