INNERVATION, ACTIVATION AND FORCES OF PERIORAL MUSCLES

口周肌肉的神经支配、激活和力量

• 批准号: 6379708
• 负责人: CHRISTOPHER D MARSHALL
• 金额: $ 2.06万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6379708
• 关键词: bone development; craniofacial; electromyography; facial muscles; facial nerve; innervation; muscle contraction; oral pharyngeal; swine

The proposed study will correlate perioral innervation, perioral muscle activity, and forces generated by perioral muscles in pigs. Perioral muscles of the lips comprise a type of muscular hydrostat. Their unique architecture allows highly coordinated movements. These intricate movements depend upon the pattern of innervation by cranial nerve VII. To understand the basis of perioral muscle contraction, we will perform nerve stimulations in order to assign functions and map motor unit territories. In vivo coordinated activity patterns of perioral muscles are unknown in laboratory animals, and little studied even in humans. Perioral muscles are often presumed to have a higher activity frequency and greater duration of contraction than masticatory muscles, which in turn is thought to influence bone growth. Therefore, we plan to investigate the activity patterns of perioral musculature. The forces generated by perioral muscle contraction are germane to the putative role of these muscles as contributing factors in malocclusions. It is possible that they exert pressure normal to the underlying bone surface. We will investigate bone strain and pressure generated by perioral musculature. The extent to which forces from these muscle influence craniofacial development is virtually unexplored and is the study's ultimate goal.

拟议的研究将与猪的周围肌肉产生的周围神经支配，周围肌肉活性和力相关联。 嘴唇的周围肌肉包括一种肌肉氢化器。 它们独特的架构允许高度协调的运动。 这些复杂的运动取决于颅神经VII的神经支配模式。 为了理解牙性肌肉收缩的基础，我们将进行神经刺激，以分配功能并绘制运动单位区域。 在实验动物中，围绕肌肉的体内协调活性模式是未知的，即使在人类中也很少研究。与咀嚼肌相比，通常认为牙性肌肉具有更高的活性频率和更高的收缩持续时间，而咀嚼肌则被认为会影响骨骼的生长。因此，我们计划研究周围肌肉组织的活性模式。 周围肌肉收缩产生的力与这些肌肉的假定作用是造成障碍因素的推定作用。 它们可能施加正常的压力与下面的骨表面。 我们将研究周围肌肉组织产生的骨骼应变和压力。 这些肌肉的力量影响颅面发育的程度几乎没有探索，这是该研究的最终目标。