INTERNATIONAL CENTERS AGAINST ORAL CANCER

国际口腔癌中心

• 批准号: 6379993
• 负责人: Stimson P Schantz
• 金额: $ 14.09万
• 依托单位: STRANG CANCER PREVENTION CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379993
• 关键词: alcoholism /alcohol abuse; cancer risk; chemoprevention; clinical research; cooperative study; environmental exposure; genetic susceptibility; human subject; neoplasm /cancer epidemiology; oral pharyngeal neoplasm; passive smoking; tobacco abuse

The pursuit of international collaborative research efforts will lead to effective strategies which lower oral cancer incidence and mortality. We present a two year planning proposal based on a multi-institutional collaboration consisting of the Strang Cancer Prevention Center, New York Medical College, and American Health Foundation in New York City, the AC Camargo Cancer Center/Ludwig Institute for Research in Sao Paulo, Brazil, the Free University Hospital in Amsterdam, the Netherlands, the National Cancer Center of Singapore, and the Tata Memorial Center in Bombay. These combined centers evaluate over 3000 oral cancer patients annually. Combined with an experienced team of scientists with expertise in epidemiology, carcinogenesis, tumor and molecular biology, and clinical trials, this collaborative team is well-equipped to address critical questions in oral oncology. Specifically, we propose to: 1) Develop a case-control international epidemiologic trial to investigate factors responsible for changing trends in oral cancer incidence; specifically, an increased incidence of oral cancer in the young adult; 2) Add measures of genetic susceptibility to the case- control study in order to enhance risk factor estimates. Genetic susceptibility markers will likewise be evaluated as a contributing factor to disease in the young adult population; 3) Determine the impact of levels of environmental exposures including the various forms of tobacco and alcohol identified in the case-control study on the pattern of genetic mutations within oral cancers. The optimal molecular measures and standardization of molecular assays will be established during this planning period; and 4) Develop a chemopreventive strategy in high risk populations for oral cancer. The proposed planning period will provide for project development. It will establish feasibility of conducting subsequent detailed protocols. Plans for additional centers will be implemented as necessary in order to meet objectives. The end result will be a strong collaborative multi-national team of investigators with demonstrable capacity to address critical issues in head and neck oncology.

追求国际协作研究工作将导致有效的策略，以降低口腔癌的发病率和死亡率。 我们提出了一项为期两年的计划提案，该计划基于一项多机构的合作，由纽约市的Strang癌症预防中心，纽约医学院和美国健康基金会组成，AC Camargo癌症中心/巴西SAO Paulo的AC Camargo Cancer Center/Ludwig研究所，巴西自由大学医院，阿姆斯特丹，荷兰，国家癌症中心，纽约州阿姆斯特丹医院。 这些联合中心每年评估3000多名口腔癌患者。 结合一支经验丰富的科学家团队，具有流行病学，癌变，肿瘤和分子生物学以及临床试验方面的专业知识，该协作团队有能力解决口腔肿瘤学中的关键问题。 具体而言，我们建议：1）开发一项病例对照国际流行病学试验，以调查负责不断变化口腔癌发病趋势的因素；具体而言，年轻人口腔癌的发生率增加了。 2）在病例控制研究中添加遗传敏感性的度量，以增强风险因素估计。同样，将评估遗传敏感性标志物作为年轻人疾病的促成因素。 3）确定环境暴露水平的影响，包括病例对照研究中对口服癌症内遗传突变模式的各种形式的烟草和酒精的影响。 在此计划期间将建立最佳分子测量和分子测定的标准化； 4）在口腔癌的高风险种群中制定化学预防策略。 拟议的计划期将为项目开发提供。 它将确定执行随后的详细协议的可行性。 为了实现目标，将根据需要实施其他中心的计划。 最终结果将是一个强大的合作跨国调查人员团队，其能力可证明解决头颈肿瘤学的关键问题。