BEHAVIORAL AND NEURAL PLASTICITY IN FOOD-STORING BIRDS

食物储存鸟类的行为和神经可塑性

• 批准号: 6293604
• 负责人: MICHAEL W SHIFLETT
• 金额: $ 3.64万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-16 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6293604
• 关键词: animal food; behavioral /social science research tag; circadian rhythms; cognition; developmental neurobiology; ethology; experience; exploratory behavior; hippocampus; hormone regulation /control mechanism; interhemispheric transfer; learning; lidocaine; melatonin; memory; neural information processing; neural plasticity; neurogenesis; neuropsychological tests; neurotransmitter antagonist; neurotransmitter receptor; songbirds; space perception; statistics /biometry; visual perception

DESCRIPTION:(adapted from applicant?s abstract) This research project examines learning and plasticity in the hippocampus of food-storing birds. The first three experiments address the role of the hippocampus in spatial memory processing, through the use of reversible inactivation or injection of receptor antagonists. The fourth experiment examines factors that may induce seasonal neurogenesis by manipulating experience and hormone levels. This research will contribute to our understanding of the neural basis of learned behaviors in the following ways; first, by studying a natural behavior, we can increase the generality and validity of our current theories on the neural basis of learning and memory. Second, by studying a system with remarkable adult neural plasticity, we may better understand the link between plasticity in the nervous sytem and changes in cognitive function. This in turn may be relevant to therapeutic strategies involving brain repair, by revealing the mechanisms through which adult generated neurons become functionally integrated into the nervous system.

描述：（改编自申请人的摘要） 该研究项目研究了海马的学习和可塑性 食品存储鸟。前三个实验解决了 通过使用可逆的空间内存处理中的海马 失活或注射受体拮抗剂。第四实验 检查可能通过操纵季节性神经发生的因素 经验和激素水平。这项研究将有助于我们 了解以下方式对学习行为的神经基础的理解； 首先，通过研究自然行为，我们可以提高一般性和 我们当前理论的有效性是基于学习和记忆的神经基础。 其次，通过研究具有显着成人神经可塑性的系统，我们可以 更好地了解神经系统中的可塑性与变化之间的联系 在认知功能中。反过来，这可能与治疗策略有关 通过揭示成人的机制，涉及大脑修复 产生的神经元在功能上积分为神经系统。