MINORITY PREDOCTORAL FELLOWSHIP PROGRAM

少数族裔博士前奖学金计划

• 批准号: 6385215
• 负责人: LEILAH D MCNABB
• 金额: $ 3.36万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6385215
• 关键词: alleles; drug adverse effect; drug hypersensitivity; drug interactions; gene expression; genetic polymorphism; pharmacogenetics; phenotype; physical chemical interaction; postgraduate education

No thesis topic has been selected at this point. My primary field of interest, however is pharmacogenetics. How drugs exert their effects, both good and bad, has always been a subject of great interest. How drugs exert their effects both good and bad, has always been a subject of great interest. I am particularly interested in individual variations in drug response. Since pharmacogenetics is the field most closely aligned with this interest, it is my field of choice. I believe that by using pharmacogenetics to delineate genetic polymorphisms, or rare variant alleles that increase susceptibility to adverse drug reactions, these toxic and adverse reactions will be greatly lessened in the future. Patients will be able to be genotyped before taking certain drugs, to pre-determine if they are risk for toxicity. If they are found to have the susceptibility polymorphism, than an alternate mode of therapy can be substituted. I believe that in the area of the Human Genome Project, this type of knowledge is even more attainable. Pharmacogenetics research will revolutionize drug therapy as we know it, making it less toxic and more individualized. It is for these reasons that pharmacogenetics is an extremely exciting field in which I plan to study.

目前尚未选择论文主题。然而，我主要感兴趣的领域是药物遗传学。药物如何发挥其作用，无论是好的还是坏的，一直是人们非常感兴趣的话题。药物如何发挥其好的和坏的作用一直是人们非常感兴趣的话题。我对药物反应的个体差异特别感兴趣。由于药物遗传学是与这种兴趣最密切相关的领域，因此它是我的选择领域。我相信，通过药物遗传学来描述遗传多态性，或者增加药物不良反应易感性的罕见变异等位基因，这些毒性和不良反应在未来将会大大减少。患者将能够在服用某些药物之前进行基因分型，以预先确定他们是否有毒性风险。如果发现它们具有敏感性多态性，则可以替代替代治疗模式。我相信在人类基因组计划领域，这种知识更加容易获得。药物遗传学研究将彻底改变我们所知的药物治疗，使其毒性更小、更个性化。正是由于这些原因，药物遗传学成为我计划研究的一个非常令人兴奋的领域。