CANCER GENETICS

癌症遗传学

• 批准号: 6501412
• 负责人: Richard D Kolodner
• 金额: $ 18.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-21 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501412
• 关键词: animal genetic material tag; brca gene; gene induction /repression; gene mutation; laboratory mouse; linkage mapping; microarray technology; neoplasm /cancer genetics; oncogenes

The Cancer Genetics Program consists of 12 Participating Members, representing total peer-reviewed funding of $5.1 Million in annual direct costs (7.3 Million in total costs). During the last two years, its Members generated a total of 106-cancer-relevant peer-reviewed publications, 7% of which were intra- and inter-programmatic collaborations. The Cancer Genetics Program is focused on using classical and molecular genetics in the study of cancer, both for understanding the mechanistic basis of the disease and for developing therapeutic interventions. The information coming onstream from Human Genome Project and the availability of tools for use in mutation detection, linkage analysis, positional cloning and candidate gene analysis have facilitated the gene discovery process. This is resulting in the continuing identification of genetic abnormalities involved in the development of various types of cancer. Additionally, the ready availability of experimental methods for the genetic modification of various types of cancer. Additionally, the ready availability of experimental methods for the genetic modification of both mouse and human cells have allowed investigators to study the significance and functional implications of these newly recognized abnormalities for the development and treatment of cancer directly in mammalian systems. Rapid progress in understanding model organisms like yeast, De. Melanogaster, X laevis and C. elegans, coupled with the realization that many molecular pathways that are important in the development of cancer in higher species and mammalian cells are conserved in model organisms, has led to the productive introduction of studies of such organisms into cancer research. Integrated application of these different but complementary approaches to mammalian genetics unify and accelerate our understanding of the interlocking disturbances in the structural and regulatory components of the genome which characterize the onset of neoplasia. To take advantage of these developments and bring them to bear on the cancer research program at UCSD, the Cancer Genetics Program has put emphasis on studying (1) Cancer-relevant Model Systems; (2) Mouse Cancer Genetics; (3) Mammalian Cancer Genetics and; (4) Clinical Cancer Genetics.

癌症遗传学计划由12名参与成员组成，代表了同行评审的总资​​金510万美元的直接成本（总费用为730万）。在过去的两年中，其成员共同产生了106名与同行评审的出版物，其中有7％是内部和程序间合作。癌症遗传学计划的重点是在癌症的研究中使用经典和分子遗传学，既是用于了解疾病的机械基础和发展治疗干预措施。从人类基因组项目中引入的信息以及用于突变检测，链接分析，位置克隆和候选基因分析的工具的可用性促进了基因发现过程。这导致持续确定各种类型癌症发展涉及的遗传异常。另外，实验方法的现成可用性用于各种类型癌症的遗传修饰。此外，实验方法的现成可用性用于小鼠和人类细胞的遗传修饰，使研究人员可以直接在哺乳动物系统中直接研究这些新公认的对癌症发展和治疗癌症的显着性和功能意义。理解模型生物（如酵母），de的快速进步。 Melanogaster，X laevis和C.秀丽隐杆线虫，再加上认识到，许多在较高物种和哺乳动物细胞在模型生物中保守的许多分子途径在模型生物中保守，这导致了此类生物体研究的生产性引入癌症研究。这些不同但互补的哺乳动物遗传学方法的综合应用统一并加速了我们对基因组结构和调节成分的互锁干扰的理解，该结构和调节成分表征了肿瘤的发作。为了利用这些发展，并将它们带入UCSD的癌症研究计划，癌症遗传学计划重点是研究（1）与癌症相关的模型系统； （2）小鼠癌遗传学； （3）哺乳动物癌遗传学和； （4）临床癌症遗传学。