CORE--MASS SPECTROMETRY

核心——质谱

• 批准号: 6469210
• 负责人: DOUGLAS J BEUSSMAN
• 金额: $ 21.7万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6469210
• 关键词: biomedical equipment resource; biomedical facility; electrospray ionization mass spectrometry; mass spectrometry; neoplasm /cancer; oncology

The Mass Spectrometry Shared Resource provides critical services to Cancer Center members whose research relies on structure determination of a variety of different molecules. Services currently provided by the Shared Resource include high and low resolution fast atom bombardment (FAB) ionization, high and low resolution electron ionization (El), and high and low resolution chemical ionization (CI). After the installation of. two new instruments, mass spectrometry services will be expanded to include high and low resolution electrospray ionization (ESl), tandem mass spectrometry (MSIMS), and LC-MS capabilities. Except for low resolution El and CI analyses, the Shared Resource is the only location at Purdue University where the above mass spectrometry techniques can be performed. This facility is overwhelmingly utilized for cancer-related research and derives considerable benefit from its participation in the Campus-Wide Mass Spectrometry Center (CWMSC), which insures service to the entire cancer research community at Purdue University. The Mass Spectrometry Shared Resource, in conjunction with the CWMSC, has several goals including: I) coordinating the operation and maintenance of mass spectrometers used for routine analyses, 2) providing research groups working on cancer related problems with access to all of the mass spectrometry technology on campus, 3) increasing awareness of the opportunities for problem solving by mass spectrometry, 4) coordinating the acquisition of new instrumentation as needs arise, and 5) developing new methods required to analyze user samples. Cancer Center members derive considerable benefit from the instrumentation and expertise provided by this Shared Resource and its personnel.

质谱共享资源为癌症中心成员提供了关键的服务，他们的研究依赖于各种不同分子的结构确定。共享资源当前提供的服务包括高分辨率和低分辨率快速原子轰击（FAB）电离，高和低分辨率电子电离（EL）以及高分辨率化学电离（CI）。安装后。两种新仪器将扩大质谱服务，包括高分辨率电喷雾电离（ESL），串联质谱（MSIMS）和LC-MS功能。除了低分辨率EL和CI分析外，共享资源是普渡大学唯一可以执行上述质谱技术的位置。该设施绝大多数用于与癌症相关的研究，并从参与校园范围内的质谱中心（CWMSC）中获得了可观的好处，该中心为普渡大学的整个癌症研究界提供服务。 The Mass Spectrometry Shared Resource, in conjunction with the CWMSC, has several goals including: I) coordinating the operation and maintenance of mass spectrometers used for routine analyses, 2) providing research groups working on cancer related problems with access to all of the mass spectrometry technology on campus, 3) increasing awareness of the opportunities for problem solving by mass spectrometry, 4) coordinating the acquisition of new instrumentation as needs arise, 5）开发分析用户样本所需的新方法。癌症中心成员从该共享资源及其人员提供的仪器和专业知识中获得了可观的好处。