PREDNISONE & FISH OIL SUPPLEMENTS IN CHILDREN & YOUNG ADULTS W/ IGA NEPHROLOGY

强的松

• 批准号: 6303457
• 负责人: JOSEPH T FLYNN
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6303457
• 关键词: IgA nephropathy; child (0-11); clinical research; clinical trials; diet therapy; dietary supplements; hormone therapy; human subject; human therapy evaluation; kidney function; marine animal oil; nutrition related tag; prednisone; young adult human (21-34)

IgA nephropathy is a disease of the kidneys which leads to loss of blood and protein in the urine and can lead to severe kidney failure even when it begins in childhood. Unfortunately, there is no proven treatment for IgA nephropathy, although a few reports have described the successful treatment of patients with this condition with either fish oil supplements or a medication called prednisone. Those taking part will be asked to participate in a 5-year clinical trial which will compare every-other-day prednisone or daily fish oil capsules with a placebo (a pill which contains no medicine) in the treatment of my IgA nephropathy. The purpose of this study to be the evaluation of whether fish oil supplements or alternate-day prednisone can prevent or slow the decline in kidney function expected in children, adolescents and young adults with moderate to severe IgA nephropathy. Neither the doctor or patient will be told which one of the three treatments they are taking.

IGA肾病是肾脏的一种疾病，导致尿液中血液和蛋白质的损失，即使在儿童时期开始，也可能导致严重的肾衰竭。 不幸的是，尽管有一些报道描述了使用鱼油补充剂或称为泼尼松的药物对患有这种疾病的患者的成功治疗，但尚无对IGA肾病的可靠治疗。参与的人将被要求参加为期5年的临床试验，该试验将将每天的泼尼松或每日鱼油胶囊与安慰剂（一种不含药物的药丸）进行比较，以治疗我的IGA肾病。 这项研究的目的是评估鱼油补充剂或替代泼尼松是否可以预防或减缓患有中度至重度IgA肾病的儿童，青少年和年轻人预期的肾脏功能下降。 医生或患者都不会被告知他们要接受的三种治疗方法中的哪一种。