SUBCLINICAL CARDIOVASCULAR DISEASE STUDY

亚临床心血管疾病研究

• 批准号: 6370030
• 负责人: RUSSELL P TRACY
• 金额: --
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2009-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6370030
• 关键词: African American; Chinese American; Hispanic Americans; atherosclerosis; cardiovascular disorder epidemiology; caucasian American; clinical chemistry; clinical research; coronary disorder; disease /disorder proneness /risk; early diagnosis; human middle age (35-64); human old age (65+); human subject; mass screening; noninvasive diagnosis; prognosis; racial /ethnic difference

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84.大约40％的队列将为白人，30％的非裔美国人，20％的西班牙裔和10％的中国裔美国人。 该队列将从六个野外中心招募，并在各种亚临床心血管疾病措施，标准冠状动脉危险因素，社会人口统计学因素，生活方式因素和社会心理因素方面进行特征。 将对假定的生化危险因素进行测定，并存储用于病例对照研究。 DNA将被提取并使淋巴细胞永生化，以研究候选基因和可能全基因组扫描的研究。 计划进行四次临床检查，分别为18-24个月。将遵循参与者的鉴定和表征心血管疾病事件和接受的干预措施。

项目成果

Differences in the incidence of congestive heart failure by ethnicity: the multi-ethnic study of atherosclerosis.

• DOI: 10.1001/archinte.168.19.2138
• 发表时间: 2008-10-27
• 期刊: ARCHIVES OF INTERNAL MEDICINE
• 作者: Bahrarni, Hossein;Kronmal, Richard;Bluemke, David A.;Olson, Jean;Shea, Steven;Liu, Kiang;Burke, Gregory L.;Lima, Joao A. C.
• 通讯作者: Lima, Joao A. C.

Combining data from primary and ancillary surveys to assess the association between neighborhood-level characteristics and health outcomes: the Multi-Ethnic Study of Artherosclerosis.

结合主要和辅助调查的数据来评估社区特征与健康结果之间的关联：动脉粥样硬化的多种族研究。

• DOI: 10.1002/sim.3384
• 发表时间: 2008
• 期刊: Statistics in medicine
• 影响因子: 2
• 作者: Sánchez,BN;Raghunathan,TE;DiezRoux,AV;Zhu,Y;Lee,O
• 通讯作者: Lee,O