DIURNAL VERSUS NOCTURNAL INDUCTION OF LABOR

白天与夜间引产

• 批准号: 6264916
• 负责人: KENNETH K CHAN
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264916
• 关键词: birth; circadian rhythms; clinical research; female; human pregnant subject; human subject; human therapy evaluation; women's health

Currently, in clinical obstetrics, 10-30% of pregnancies are induced for a variety of maternal and fetal indications ranging from post dates, deteriorating maternal condition, to social reasons. Most inductions are started in the morning using pitocin, the synthetic form of the hormone oxytocin, and infused for eight to ten hours. The failure rates of inductions range from 20-50%, resulting in multiple day trials and ultimately a Ceasarian section rate as high as 50%. Because there is a circadian rhythm in human labor such that spontaneous contractility and uterine sensitivity to oxytocin is maximal at night, we propose to compare the efficacy and duration of diurinal versus nocturnal induction of labor.

目前，在临床产科中，10-30% 的妊娠是由于各种母体和胎儿适应症而引产的，包括过期妊娠、母体状况恶化和社会原因等。 大多数引产都是在早上开始，使用催产素（催产素的合成形式），并输注八到十个小时。 引产失败率在 20-50% 之间，经过多天的试验，最终剖腹产率高达 50%。 由于人类分娩存在昼夜节律，自发收缩力和子宫对催产素的敏感性在夜间达到最大，因此我们建议比较日间引产与夜间引产的功效和持续时间。