EFFECT OF INSULIN ON LUTEINIZING HORMONE (LH) RELEASE IN WOMEN

胰岛素对女性黄体生成素 (LH) 释放的影响

• 批准号: 6308004
• 负责人: ANN E TAYLOR
• 金额: $ 0.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308004
• 关键词: clinical research; clinical trial phase I; diazoxide; endocrine pharmacology; female; follicle stimulating hormone; hormone regulation /control mechanism; human subject; insulin; luteinizing hormone; sex hormones

Subjects will be admitted to the GCRC within the first 3 days after the onset of menses, or at random in amenorrhcic subjects. After an overnight fast, they will undergo 24 hours of q 10 minute blood sampling (2-3 cc per sample) for LH glucose and insulin levels. Serum pools will be tested for FSH and sex steroids. During this stay, meals will be standardized at 0830, 1200, 1500, 1800, and 2230 hrs., with calories adjusted to maintain body weight. Diazoxide 100 mg po q 8 hr will be initiated for 4 days. They will be readmitted after an overnight fast for repeat sampling under the identical protocol. Analysis: Paired t-testing within and unpaired t-testing between groups.

在月经开始后的前三天，或在闭经症受试者中随机接纳受试者的GCRC。 快速过夜后，他们将进行24小时的Q 10分钟抽样（每样品2-3 cc），以进行LH葡萄糖和胰岛素水平。 血清池将用于FSH和性类固醇。 在此期间，餐点将在0830、1200、1500、1800和2230小时的标准化中进行标准化，并调整了卡路里以保持体重。 二氮杂100毫克PO Q 8小时将启动4天。在隔夜快速后，将在相同的协议下重复采样后将其重复。 分析：组之间和未配对的t测试t之间的t配对。