ADAPTIVE IMMUNITY SUPPORTS SCHISTOSOME DEVELOPMENT

适应性免疫支持血吸虫的发展

• 批准号: 6362261
• 负责人: Stephen J Davies
• 金额: $ 4.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6362261
• 关键词: B lymphocyte; Schistosoma mansoni; T lymphocyte; cell population study; cellular immunity; cytokine; enzyme linked immunosorbent assay; gene expression; genetic transcription; host organism interaction; intracellular parasitism; laboratory mouse; leukocyte activation /transformation; life cycle; northern blottings; pathologic process; polymerase chain reaction; schistosomiasis; statistics /biometry; tumor necrosis factor alpha

DESCRIPTION Infections with parasitic trematodes of the genus Schistosoma affect 200 million people worldwide, primarily in developing countries. Studies involving S. mansoni have suggested that successful completion of parasite development and migration within the mammalian host is dependent on the receipt of appropriate host-derived signals by the parasite and on transmission of signals between male and female parasites. A molecular understanding of the signals and receptors involved in these interactions may reveal new opportunities to disrupt the parasite life cycle for therapeutic or prophylactic purposes. We have now found that normal development of S. mansoni in the murine host is dependent on adaptive immune responses mounted by the host during prepatency. The aims of this proposal are to (i) identify the precise immune cells and factors responsible for promoting parasite development, and (ii) identify parasite molecules involved in mediating phenotypic plasticity to host factors. The ultimate goal of this work is to identify novel mechanisms for disrupting the parasite life cycle for therapeutic and prophylactic purposes

描述具有寄生虫的寄生虫感染的描述，主要在发展中国家，主要在全球影响全球。涉及曼氏链球菌的研究表明，在哺乳动物宿主内成功完成寄生虫的发展和迁移取决于寄生虫通过寄生虫收到适当的宿主信号，以及在雄性和女性寄生虫之间传播信号。对这些相互作用所涉及的信号和受体的分子理解可能会揭示出新的机会，以破坏寄生虫生命周期以治疗或预防性目的。我们现在发现，鼠宿主中曼氏链球菌的正常发育取决于宿主在预征载体期间安装的适应性免疫反应。该提案的目的是（i）确定促进寄生虫发育的精确免疫细胞和因素，以及（ii）确定参与介导表型可塑性为宿主因素的寄生虫分子。这项工作的最终目标是确定破坏寄生虫生命周期的新型机制