BIRTH RISK AND SEVERE MENTAL DISORDERS IN DENMARK

丹麦的出生风险和严重精神障碍

• 批准号: 6286278
• 负责人: WILLIAM W EATON
• 金额: $ 20.8万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6286278
• 关键词: Asperger syndrome; Scandinavian country; autism; bipolar depression; case history; clinical research; disease /disorder proneness /risk; family genetics; hospital utilization; human data; labor complications; mental disorders; mental health epidemiology; mood disorders; schizophrenia; social mobility; socioeconomics

DESCRIPTION (Applicant's Abstract): It is now accepted that pregnancy and birth complications (PBC's) are associated with increased risk for schizophrenia. It is not known whether PBC's are associated with increased risk for bipolar disorder and other affective psychoses; whether the increase in risk is explained by life style factors of the mother associated with lower socioeconomic status; whether the increased risk is an expression of genetic predisposition to disorder; whether PBC'S, and/or family history of disorder, are associated with early age of onset; the degree to which intergenerational transmission of socioeconomic status is explained by PBC's, in the general population; and in general, how the major risk factors for severe mental disorders combine in raising risk. Continuation of research on the relationship of PBC's to severe mental disorder (especially schizophrenia, bipolar disorder, autism, and their associated disorders) is proposed. Prior analyses, based on linkage of the medical birth register and psychiatric case register of Denmark for births 1973-1993, showed that PBC's were related prospectively to the entire range of hospitalized mental disorders, in both adults and children, with the possible exception of affective psychosis. This continuation expands: 1) the data collection years through 1999; 2) the case-finding beyond hospitals to include specialty outpatient clinics; and 3) the linkage to include the Central Population Register and the National Bureau of Statistics. A reference sample of 5 percent sample of the population of Denmark, including over 60,000 births after 1973 will be linked as well. The expansion will: 1) generate an expected 1200 cases of schizophrenia, 350 cases of affective psychosis, and 1150 cases of autism; 2) permit linkage of first degree relatives, including siblings, mothers and fathers; and 3) permit linkage to socioeocomic variables, obtained on yearly basis, when taxes are paid, such as occupation, income, education, employment, and wealth. Analytic procedures are mostly in the form of logistic regression, and its extensions to time-to-event models (Proportional Hazards); dependent variables with more than two categories (Polytomous Logistic); and to dependent observations (Generalized Estimating Equations). Denmark's system of social medicine provides free care for all, minimizing leakage of cases; and the system of registers is as highly developed and reliable as anywhere in the world. Results will clarify the etiologies of the severe mental disorders; improve understanding of nosologic relationships between the several disorders; provide quantitative information relevant to planning of longitudinal observational and preventive intervention research; and suggest subsets of cases to improve power for genetic analyses.

描述（申请人的摘要）：现在接受怀孕和出生 并发症（PBC）与精神分裂症的风险增加有关。它 尚不知道PBC是否与双极性风险增加有关 混乱和其他情感精神病；风险的增加是 由母亲的生活风格因素解释 社会经济地位；增加的风险是否是遗传的表达 倾向于混乱；无论是PBC和/或家族障碍的家族史， 与发病年龄有关；代际的程度 PBC的传播在一般情况下解释了社会经济地位 人口;通常，严重精神的主要风险因素如何 疾病结合了增加风险。 继续研究PBC与严重精神障碍的关系 （尤其是精神分裂症，躁郁症，自闭症及其相关的 提出了疾病）。先前的分析，基于医学出生的联系 1973 - 1993年出生的丹麦注册和精神病病例登记册 PBC与整个住院期间有关 成人和儿童的精神障碍，可能 情感精神病。这种延续扩展：1）数据收集年 到1999年； 2）除医院以外的病例调查以包括专业 门诊诊所； 3）链接包括中央人口 注册和国家统计局。 5％的参考样本 丹麦人口的样本，包括1973年以后的60,000多个出生 也将链接。扩展将：1）产生预期的1200箱 精神分裂症，350例情感精神病病例和1150例自闭症病例； 2）允许一级亲戚的联系，包括兄弟姐妹，母亲和 父亲； 3）允许与每年获得的社会核心变量联系 基础，当缴税时，例如职业，收入，教育，就业， 和财富。 分析程序主要以逻辑回归的形式及其形式 扩展到事实模型（比例危害）；因变量 有两个以上的类别（多态逻辑）；并依赖 观察（广义估计方程）。丹麦的社会体系 医学为所有人提供免费护理，最大程度地减少病例泄漏；和 注册系统与任何地方一样高度发达和可靠 世界。结果将阐明严重精神障碍的病因； 提高对几种疾病之间的病因关系的理解； 提供与纵向计划有关的定量信息 观察和预防性干预研究；并建议子集的子集 改善遗传分析功率的案例。