TELEMETRY OF CARDIOVASCULAR RESPONSES

心血管反应遥测

• 批准号: 6116301
• 负责人: ORVILLE A SMITH
• 金额: $ 8.67万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6116301
• 关键词: Mammalia; Primates; cardiovascular system; endocrine gland /system; nervous system; psychology

The aim of this research is to understand how the circulatory system is controlled, with the ultimate objective of determining which control factors are most directly involved in the production of essential hypertension. Over the past year we phased out the baboon research. In one aspect of the work we completed the lesions of the HACER (hypothalamic area controlling emotional responses), a region of the hypothalamus. Data analyses showed a dramatic correlation between the resting level of blood pressure and the decrease in that pressure level after hypothalamic lesions. Retrospective analysis of data obtained since 1986 showed that animals with spontaneous hypertension were returned to normotensive levels. In the second aspect, we found that dominant male baboons in social situations showed significantly elevated heart rate, blood pressure, and catecholamines during the presentation of food, whereas subordinate males did not show elevations in these variables.

本研究的目的是了解循环系统是如何控制的，最终目标是确定哪些控制因素最直接地参与原发性高血压的产生。 在过去的一年里，我们逐步停止了对狒狒的研究。 在工作的一方面，我们完成了 HACER（控制情绪反应的下丘脑区域）（下丘脑的一个区域）的损伤。 数据分析显示，静息血压水平与下丘脑损伤后血压水平下降之间存在显着相关性。 对 1986 年以来获得的数据进行回顾性分析表明，患有自发性高血压的动物血压恢复到正常水平。 在第二个方面，我们发现，在社交场合中占主导地位的雄性狒狒在提供食物时心率、血压和儿茶酚胺含量显着升高，而从属雄性狒狒在这些变量上没有表现出升高。