CONFERENCE ON DENDRITIC CELLS

树突状细胞会议

• 批准号: 6287411
• 负责人: Ralph Marvin Steinman
• 金额: $ 0.85万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-07 至 2002-03-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6287411
• 关键词: antigen presentation; cell biology; dendritic cells; meeting /conference /symposium

DESCRIPTION: (Adapted from Applicant s Abstract) Dendritic cells (DCs) are recognized as the key controllers of the immune system, including immune aspects of clinical medicine. DC biology continues to develop in significant and surprising ways. There are new subsets of DCs with different functions; new maturation stimuli that control the initiation of immunity; new markers to visualize DCs in lymphoid tissues and pathologic states; new molecular mechanisms that control DC migration and lifespan; and new therapies aimed at manipulating DC physiology. Therefore, it is straightforward to devote an entire meeting to DCs themselves. However, it is additionally important to emphasize the developments in DC biology that interface with other active areas of immunobiology and medicine. The main interfaces of this multidisciplinary meeting comprise 1) the cell biology of antigen presentation, including the regulated function of intracellular MHC II compartments, the exogenous pathway for presentation on MHC class I, and nonclassical presenting molecules like CD1; 2) T cell costimulation, including the clustering of MHC and accessory molecules to form the immunological synapse; 3) the role of DCs in the regulation of T cell function, including Thl/Th2 subsets, regulatory T cells, and peripheral tolerance; 4) the interaction of infectious agents with DCs, including emerging viral vectors for expression of recombinant genes; and 5) human immunotherapy, using DCs as adjuvants. The meeting will highlight the participation of younger scientists through the inclusion of longer talks by rising new investigators, shorter presentations selected from the abstracts, and several workshops in critical areas. The program and the breadth of participation will make this meeting a must for the many students and postdocs who are now providing the advances in this field.

描述：（改编自申请人的摘要）树突状细胞（DC）是 被认为是免疫系统的关键控制者，包括免疫 临床医学方面。 DC生物学继续在重大领域发展 和令人惊讶的方式。 存在具有不同功能的新 DC 子集； 控制免疫启动的新成熟刺激；新标记 淋巴组织和病理状态中 DC 的可视化； 新分子 控制 DC 迁移和寿命的机制；和新疗法旨在 操纵 DC 生理学。 因此，直接投入 整个会议由 DC 自己负责。 然而，另外重要的是 强调 DC 生物学与其他活性物质相互作用的发展 免疫生物学和医学领域。 这个的主要接口 多学科会议包括1)抗原的细胞生物学 介绍，包括细胞内 MHC II 的调节功能 区室，MHC I 类呈递的外源途径，以及 非经典呈递分子，如 CD1； 2）T细胞共刺激，包括 MHC 和辅助分子聚集形成免疫学 突触； 3）DC在T细胞功能调节中的作用，包括 Thl/Th2 亚群、调节性 T 细胞和外周耐受； 4） 感染因子与 DC 的相互作用，包括新出现的病毒载体 用于重组基因的表达； 5）人类免疫疗法，使用DC作为 佐剂。会议将突出年轻科学家的参与 通过增加新调查人员进行的更长的谈话，更短的 从摘要中选出的演讲以及批判性的几个研讨会 地区。会议的议程和参与的广度将使本次会议成为 对于现在正在提供进步的许多学生和博士后来说必须 这个领域。