Conference--Calpain Gene Family in Health and Disease

会议--健康与疾病中的钙蛋白酶基因家族

• 批准号: 6318089
• 负责人: RONALD L MELLGREN
• 金额: $ 0.6万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6318089
• 关键词: calpain; disease /disorder; health; meeting /conference /symposium; protein structure function; travel

Support is requested for a FASEB Summer Research Conference on "Calpain Gene Family in Health and Disease" to be held June 30 through July 5, 2001 at The Big Mountain resort in Whitefish, Montana. The calpains are regulated intracellular proteases which participate in a variety of signal transduction pathways, are involved in cytoskeletal remodeling in physiologic and pathophysiologic conditions, and appear to participate in some apoptotic pathways. Several of the calpain family members require the intracellular second messenger Ca2+ for activity. The conference is meant to foster exchange of ideas and collaborations between the many diverse laboratories studying calpains. Participants will include many pioneering calpain researchers as well as young investigators who have recently begun research in this area. Topics will include: 1) Structure/function relationships of the calpains, including likely contributions on calpain crystal structure in the presence of Ca2+, or associated with the natural inhibitor protein, calpastatin. 2) Novel calpain gene family members, biochemical characterization and cellular functions. 3) Mechanisms of regulation of the ubiquitously expressed p- and m-calpains, at the cellular and molecular levels. 4) Physiologic functions of the calpains. 5) Calpains in pathology. Funding is requested to partially support travel expenses and housing for speakers, organizers and promising young investigators. Additional funding will be sought from the Muscular Dystrophy Association, and the USDA, because of calpain involvement in muscular dystrophy and muscle growth. Funding will also be requested from several drug companies which are currently conducting research on calpains. In selecting participants, preference will be given to women and under represented minorities. The speakers include virtually all of the women scientists in the field who have made substantial contributions. Four of the session chairs are women. The Big Mountain resort is a handicapped-accessible facility, and the registration form will question participants about any special needs they may have.

要求将在2001年6月30日至2001年7月5日在蒙大拿州怀特菲什的Big Mountain Resort举行关于“健康与疾病中的Calpain基因家族”的FaseB夏季研究会议的支持。 CALPAIN是参与多种信号转导途径的细胞内蛋白酶，参与生理和病理生理状况的细胞骨架重塑，并且似乎参与了一些凋亡途径。几个Calpain家族成员需要细胞内的第二信使Ca2+进行活动。该会议旨在促进许多研究Calpains的不同实验室之间的思想和合作。参与者将包括许多开创性的Calpain研究人员以及最近在该领域开始研究的年轻研究人员。主题将包括：1）CALPAIN的结构/功能关系，包括在Ca2+存在下对Calpain晶体结构的贡献，或与天然抑制剂蛋白Calpastatin相关的。 2）新型钙蛋白酶基因家族成员，生化表征和细胞功能。 3）在细胞和分子水平下，无处不在表达的P和M-钙质的调节机制。 4）钙蛋白酶的生理功能。 5）病理学中的钙。要求资金部分支持演讲者，组织者和有前途的年轻调查员的差旅费和住房。由于肌肉营养不良症和肌肉生长的参与，将从肌肉营养不良协会和USDA中寻求额外的资金。还将要求几家目前正在对Calpains进行研究的制药公司的资金。在选择参与者时，将偏爱妇女和代表的少数民族。演讲者几乎包括该领域做出了重大贡献的所有女科学家。会议椅中的四个是女性。大山度假村是一个可见的设施，注册表将质疑参与者他们可能拥有的任何特殊需求。