Conference on Frontiers of Structural Biology

结构生物学前沿会议

• 批准号: 6446615
• 负责人: JOHN KURIYAN
• 金额: $ 0.45万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6446615
• 关键词: meeting /conference /symposium; neoplasm /cancer; structural biology

DESCRIPTION (Provided by applicant): Structural biologists are deciphering the mechanisms of biological macromolecules at a breathtaking pace. X-ray crystallography has provided atomic resolution structures of complex molecular assemblies, such as the ribosome and RNA polymerase, of sizes that would have been unimaginable just a short time ago. NMR spectroscopy is allowing us to probe not just the structure, but also the dynamics, of ever larger molecules of proteins and nucleic acids in solution and in membranes. This wealth of structural information is complemented by dramatic improvements in the computational analysis of the structure and dynamics of biological macromolecules. The integration of all this new information requires an inter-disciplinary approach that utilizes a wide range of biochemical and biophysical tools to probe molecular function, while keeping the biologically important questions at center stage. The proposed Keystone Meeting will bring together structural biologists interested in these issues, which have deep implications both for fundamental biology and for the process of drug discovery.

描述（由申请人提供）： 结构生物学家正在破译生物的机制 大分子以惊人的速度发展。 X射线晶体学提供了 复杂分子组装体的原子分辨率结构，例如 核糖体和 RNA 聚合酶的大小仅是难以想象的 不久前。 核磁共振波谱使我们不仅能够探测 更大的蛋白质分子的结构以及动力学 溶液和膜中的核酸。 这种丰富的结构性 计算能力的显着改进补充了信息 生物大分子的结构和动力学分析。 这 所有这些新信息的整合需要跨学科的 该方法利用广泛的生化和生物物理工具 探索分子功能，同时保留重要的生物学问题 处于舞台中央。 拟议的基斯通会议将汇集结构性的 生物学家对这些问题感兴趣，这些问题对 基础生物学和药物发现过程。