BIOBEHAVIORAL INTERVENTIONS FOR ORAL PAIN AND MUCOSITIS

口腔疼痛和粘膜炎的生物行为干预

基本信息

批准号：
6392998
负责人：
DEBORAH B. MCGUIRE
金额：
$ 40.18万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
起止时间：
1995-02-01 至 2003-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6392998
关键词：
behavioral /social science research tag behavioral medicine bone marrow transplantation clinical research health care cost /financing health education human subject human therapy evaluation medical complication neoplasm /cancer immunotherapy oral facial pain oral health oral pharyngeal disorder patient care management prostaglandin E self care

项目摘要

Oral pain and mucositis are highly prevalent treatment side effects in cancer patients receiving autologous stem cell transplants of marrow or peripheral blood origin. Interventions are needed that address both the underlying mechanisms of mucositis and pain while simultaneously involving the family caregivers who are so important in cancer care The primary aim of this project is to test whether a comprehensive biobehavioral intervention combining misoprostol (a prostaglandin E1 analogue) with psychoeducation that systematically includes family caregivers will reduce severity of oral tissue injury and associated acute oral pain and increase adherence to oral care and pain management standards of care. The secondary aim is to analyze and compare selected costs (pain medications, nutritional support and prolonged hospital stay or readmission due to mucositis) in patients receiving misoprostol plus psychoeducation, misoprostol alone, and usual care. An experimental design will be conducted at the transplant centers of Emory University and the University of Pennsylvania. Consenting patients will be randomly assigned to usual care, misoprostol alone, or misoprostol plus psychoeducation. Mucositis, pain, adherence to oral care and pain management standards, and other relevant data will be collected prior to transplant and at five timepoints afterward until 11 days post-transplant. The study should help delineate the efficacy of a comprehensive intervention that incorporates family caregivers and lead to development of cost-effective models for managing symptoms that prepare patients and family caregivers for home management and undergoing complex medical therapies.

口腔疼痛和粘膜炎是接受骨髓或外周血来源的自体干细胞移植的癌症患者中非常普遍的治疗副作用。需要采取干预措施来解决粘膜炎和疼痛的根本机制，同时让在癌症护理中非常重要的家庭护理人员参与进来。该项目的主要目的是测试是否将米索前列醇（前列腺素 E1 类似物）与心理教育相结合的综合生物行为干预措施系统地包括家庭护理人员将减少口腔组织损伤和相关急性口腔疼痛的严重程度，并提高对口腔护理和疼痛管理护理标准的依从性。第二个目的是分析和比较接受米索前列醇加心理教育、单独使用米索前列醇和常规护理的患者的选定费用（止痛药物、营养支持和延长住院时间或因粘膜炎而再次入院）。实验设计将在埃默里大学和宾夕法尼亚大学的移植中心进行。同意的患者将被随机分配接受常规护理、单独使用米索前列醇或米索前列醇加心理教育。将在移植前以及移植后五个时间点直至移植后 11 天收集粘膜炎、疼痛、口腔护理和疼痛管理标准的遵守情况以及其他相关数据。该研究应有助于确定将家庭护理人员纳入其中的综合干预措施的有效性，并开发出具有成本效益的症状管理模型，为患者和家庭护理人员做好家庭管理和接受复杂的医疗治疗的准备。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Implementation of an oral care standard for leukemia and transplantation patients.

实施白血病和移植患者的口腔护理标准。

DOI：
10.1097/00002820-200002000-00006
发表时间：
2000
期刊：
Cancer nursing.
影响因子：
0
作者：
Yeager,KA;Webster,J;Crain,M;Kasow,J;McGuire,DB
通讯作者：
McGuire,DB

The 20 item oral mucositis index: reliability and validity in bone marrow and stem cell transplant patients.

20项口腔粘膜炎指数：骨髓和干细胞移植患者的信度和效度。

DOI：
10.1081/cnv-120005902
发表时间：
2002
期刊：
Cancer investigation
影响因子：
2.4
作者：
McGuire,DeborahB;Peterson,DouglasE;Muller,Susan;Owen,DonnaC;Slemmons,MarinaF;Schubert,MarkM
通讯作者：
Schubert,MarkM

Application of multilevel growth-curve analysis in cancer treatment toxicities: the exemplar of oral mucositis and pain.

多级生长曲线分析在癌症治疗毒性中的应用：口腔粘膜炎和疼痛的例子。