ELUCIDATION OF CHEMICAL STRUCTURES AND LARGE-SCALE SYNTHESIS OF CHEMOPROTECTORS

化学结构的阐明和化学保护剂的大规模合成

• 批准号: 6102356
• 负责人: GARY H POSNER
• 金额: $ 22.09万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6102356
• 关键词: biomedical facility; carcinogenesis inhibitor; chemical structure; drug design /synthesis /production; isothiocyanates

This Core facility provides analytical and synthetic expertise, and is specifically organized for three purposes: (a) the elucidation of chemical structures of chemoprotective enzyme inducers isolated from edible plants (Project No. 1); (b) the multigram synthesis of enzyme inducers isolated from plants (projects No.1), or identified by structure-activity studies, for evaluation as anticarcinogens in animal models (Project No. 1 and No. 3); and (c) the multigram synthesis of previously designed or identified Phase 2 enzyme inducers or their analogs for evaluation as anticarcinogens in animal systems (Project No. 1 and No. 3).

该核心设施提供分析和综合专业知识，并且 专门为三个目的而组织：(a) 阐明化学 从食用植物中分离的化学保护酶诱导剂的结构 （项目一号）； (b) 分离的酶诱导剂的多克合成 来自植物（项目 1），或通过结构活性研究鉴定， 用于动物模型抗癌剂评价（项目1号和2号） 3）； (c) 先前设计或鉴定的多重合成 用于评估抗癌剂的 2 相酶诱导剂或其类似物 动物系统（项目 1 和 3）。