A Pilot Adherence Intervention for HIV-Infected Youth

针对艾滋病毒感染青少年的试点依从性干预措施

• 批准号: 6405626
• 负责人: Sybil Hosek
• 金额: $ 3.61万
• 依托单位: JOHN H. STROGER JR. HOSPITAL OF COOK COUNTY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-11-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6405626
• 关键词: AIDS; AIDS therapy; HIV infections; adolescence (12-20); antiviral agents; behavioral /social science research tag; clinical depression; clinical research; clinical trials; cognitive behavior therapy; combination chemotherapy; coping; health behavior; human subject; human therapy evaluation; outcomes research; patient care management; psychological stressor; psychological tests; questionnaires; substance abuse related disorder; therapy compliance; young adult human (21-34)

As the numbers of adolescents and young adults with HIV continue to increase, it becomes important to develop medication adherence interventions for a group with historically low rates of adherence. Among adults living with HIV, one of the most consistently significant predictors of medication non-adherence has been depression or the presence of depressive symptomatology (Singh et al., 1996; Chesney et al., 1996). Depression has also been found to be a significant predictor of medication non-adherence among HIV-positive adolescents (Hosek, 2000). This research project aims to expand the existing HIV adherence literature by exploring the feasibility, acceptability, and effectiveness of a cognitive-behavioral depression/coping skills intervention in increasing medication adherence among HIV-infected youth. Adolescents and young adults infected with HIV will be recruited from a large midwestern public medical facility and randomly assigned to either the intervention group or the standard-care comparison group. The results from this project are important in the development and implementation of larger interventions aimed at increasing medication adherence within this population.

随着艾滋病毒艾滋病毒的青少年和年轻人的人数继续增加，为历史上依从性较低的群体制定药物依从性干预变得重要。在患有艾滋病毒的成年人中，药物不遵守的最一致的重要预测指标之一是抑郁症或抑郁症状的存在（Singh等，1996; Chesney等，1996）。还发现抑郁症是HIV阳性青少年中药物不遵守的重要预测指标（Hosek，2000）。该研究项目旨在通过探索认知行为抑郁/应对技能干预艾滋病毒感染的青年的药物依从性的可行性，可接受性和有效性来扩大现有的HIV依从性文献。感染HIV的青少年和年轻人将从中西部的大型公共医疗机构招募，并随机分配给干预组或标准护理比较组。该项目的结果对于旨在增加该人群中药物依从性的较大干预措施的开发和实施至关重要。